Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia

Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). To test the hypothesis that SCHAD-CHI arises from a specific defect in pancreatic β-cells, we created genetically engineered β-cell-spec...

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Detalles Bibliográficos
Autores principales: St-Louis, Johanna L., El Jellas, Khadija, Velasco, Kelly, Slipp, Brittany A., Hu, Jiang, Helgeland, Geir, Steine, Solrun J., De Jesus, Dario F., Kulkarni, Rohit N., Molven, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407745/
https://www.ncbi.nlm.nih.gov/pubmed/37392854
http://dx.doi.org/10.1016/j.jbc.2023.104986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407745/
https://www.ncbi.nlm.nih.gov/pubmed/37392854
http://dx.doi.org/10.1016/j.jbc.2023.104986

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