SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck

Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressive disease with poor response to immunotherapy with pembroliz...

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Detalles Bibliográficos
Autores principales: Nigam, Nupur, Bernard, Benjamin, Sevilla, Samantha, Kim, Sohyoung, Dar, Mohd Saleem, Tsai, Daniel, Robbins, Yvette, Burkitt, Kyunghee, Sievers, Cem, Allen, Clint T., Bennett, Richard L., Tettey, Theophilus T., Carter, Benjamin, Rinaldi, Lorenzo, Lingen, Mark W., Sater, Houssein, Edmondson, Elijah F., Moshiri, Arfa, Saeed, Abbas, Cheng, Hui, Luo, Xiaolin, Brennan, Kevin, Koparde, Vishal, Chen, Chen, Das, Sudipto, Andresson, Thorkell, Abdelmaksoud, Abdalla, Murali, Madhavi, Sakata, Seiji, Takeuchi, Kengo, Chari, Raj, Nakamura, Yusuke, Uppaluri, Ravindra, Sunwoo, John B., Van Waes, Carter, Licht, Jonathan D., Hager, Gordon L., Saloura, Vassiliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407766/
https://www.ncbi.nlm.nih.gov/pubmed/37463106
http://dx.doi.org/10.1016/j.celrep.2023.112823

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