Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea

Chemical exploration of solid-state cultures of the polypore Fomitopsis carnea afforded two new C31 lanostane-type triterpenoid glycosides, forpiniosides B (1) and C (2) together with two known derivatives, namely 3-epipachymic acid (3) and (3α,25S)-3-O-malonyl-23-oxolanost-8,24(31)-dien-26-oic acid...

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Autores principales: Sum, Winnie Chemutai, Ebada, Sherif S, Gonkhom, Didsanutda, Decock, Cony, Teponno, Rémy Bertrand, Matasyoh, Josphat Clement, Stadler, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407780/
https://www.ncbi.nlm.nih.gov/pubmed/37560136
http://dx.doi.org/10.3762/bjoc.19.84
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author Sum, Winnie Chemutai
Ebada, Sherif S
Gonkhom, Didsanutda
Decock, Cony
Teponno, Rémy Bertrand
Matasyoh, Josphat Clement
Stadler, Marc
author_facet Sum, Winnie Chemutai
Ebada, Sherif S
Gonkhom, Didsanutda
Decock, Cony
Teponno, Rémy Bertrand
Matasyoh, Josphat Clement
Stadler, Marc
author_sort Sum, Winnie Chemutai
collection PubMed
description Chemical exploration of solid-state cultures of the polypore Fomitopsis carnea afforded two new C31 lanostane-type triterpenoid glycosides, forpiniosides B (1) and C (2) together with two known derivatives, namely 3-epipachymic acid (3) and (3α,25S)-3-O-malonyl-23-oxolanost-8,24(31)-dien-26-oic acid (4). The structures of the isolated compounds were established based on HRESIMS and extensive 1D and 2D NMR experiments. All the isolated compounds were assessed for their antimicrobial and cytotoxic activities. Among the tested compounds, forpinioside B (1) exhibited significant antimicrobial activity against Staphylococcus aureus and Bacillus subtilis at MIC values comparable to gentamycin and oxytetracycline (positive controls), respectively.
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spelling pubmed-104077802023-08-09 Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea Sum, Winnie Chemutai Ebada, Sherif S Gonkhom, Didsanutda Decock, Cony Teponno, Rémy Bertrand Matasyoh, Josphat Clement Stadler, Marc Beilstein J Org Chem Full Research Paper Chemical exploration of solid-state cultures of the polypore Fomitopsis carnea afforded two new C31 lanostane-type triterpenoid glycosides, forpiniosides B (1) and C (2) together with two known derivatives, namely 3-epipachymic acid (3) and (3α,25S)-3-O-malonyl-23-oxolanost-8,24(31)-dien-26-oic acid (4). The structures of the isolated compounds were established based on HRESIMS and extensive 1D and 2D NMR experiments. All the isolated compounds were assessed for their antimicrobial and cytotoxic activities. Among the tested compounds, forpinioside B (1) exhibited significant antimicrobial activity against Staphylococcus aureus and Bacillus subtilis at MIC values comparable to gentamycin and oxytetracycline (positive controls), respectively. Beilstein-Institut 2023-08-02 /pmc/articles/PMC10407780/ /pubmed/37560136 http://dx.doi.org/10.3762/bjoc.19.84 Text en Copyright © 2023, Sum et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Sum, Winnie Chemutai
Ebada, Sherif S
Gonkhom, Didsanutda
Decock, Cony
Teponno, Rémy Bertrand
Matasyoh, Josphat Clement
Stadler, Marc
Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea
title Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea
title_full Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea
title_fullStr Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea
title_full_unstemmed Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea
title_short Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea
title_sort two new lanostanoid glycosides isolated from a kenyan polypore fomitopsis carnea
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407780/
https://www.ncbi.nlm.nih.gov/pubmed/37560136
http://dx.doi.org/10.3762/bjoc.19.84
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