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Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis

BACKGROUND: Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA and SNHL. METHODS: We performed a systematic rev...

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Autores principales: Lien, Kuang-Hsu, Ger, Tzong-Yun, Chi, Ching-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407832/
https://www.ncbi.nlm.nih.gov/pubmed/37094565
http://dx.doi.org/10.1159/000530784
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author Lien, Kuang-Hsu
Ger, Tzong-Yun
Chi, Ching-Chi
author_facet Lien, Kuang-Hsu
Ger, Tzong-Yun
Chi, Ching-Chi
author_sort Lien, Kuang-Hsu
collection PubMed
description BACKGROUND: Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA and SNHL. METHODS: We performed a systematic review and searched MEDLINE and Embase on July 25, 2022, for cross-sectional, case-control, or cohort studies that examined the association of AA with SNHL. The Newcastle-Ottawa Scale was used to evaluate their risk of bias. A random-effects model meta-analysis was performed to obtain the mean differences in frequency-specific hearing thresholds between AA patients and age-matched healthy controls and the pooled odds ratio for SNHL in relation to AA. RESULTS: We included 5 case-control studies and 1 cohort study, with none of them rated with high risk of biases. The meta-analysis showed AA patients had significantly higher mean differences in pure-tone hearing thresholds at 4,000 Hz and 12,000–12,500 Hz. The meta-analysis also found increased odds for SNHL among patients with AA (OR: 3.18; 95% CI: 2.06–4.89; I(2) = 0%). CONCLUSIONS: AA is associated with an increase of SNHL, especially at high frequencies. Otologic consultation may be indicated if AA patients present with hearing loss or tinnitus.
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spelling pubmed-104078322023-08-09 Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis Lien, Kuang-Hsu Ger, Tzong-Yun Chi, Ching-Chi Dermatology Systematic Review and Meta-Analysis BACKGROUND: Immune-mediated melanocyte-related pathogenesis in alopecia areata (AA) may cause sensorineural hearing loss (SNHL). However, the relation between AA and SNHL has been unclear. Therefore, we aimed to investigate this association between AA and SNHL. METHODS: We performed a systematic review and searched MEDLINE and Embase on July 25, 2022, for cross-sectional, case-control, or cohort studies that examined the association of AA with SNHL. The Newcastle-Ottawa Scale was used to evaluate their risk of bias. A random-effects model meta-analysis was performed to obtain the mean differences in frequency-specific hearing thresholds between AA patients and age-matched healthy controls and the pooled odds ratio for SNHL in relation to AA. RESULTS: We included 5 case-control studies and 1 cohort study, with none of them rated with high risk of biases. The meta-analysis showed AA patients had significantly higher mean differences in pure-tone hearing thresholds at 4,000 Hz and 12,000–12,500 Hz. The meta-analysis also found increased odds for SNHL among patients with AA (OR: 3.18; 95% CI: 2.06–4.89; I(2) = 0%). CONCLUSIONS: AA is associated with an increase of SNHL, especially at high frequencies. Otologic consultation may be indicated if AA patients present with hearing loss or tinnitus. S. Karger AG 2023-04-24 2023-08 /pmc/articles/PMC10407832/ /pubmed/37094565 http://dx.doi.org/10.1159/000530784 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Systematic Review and Meta-Analysis
Lien, Kuang-Hsu
Ger, Tzong-Yun
Chi, Ching-Chi
Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
title Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
title_full Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
title_fullStr Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
title_full_unstemmed Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
title_short Association of Alopecia Areata with Sensorineural Hearing Loss: A Systematic Review and Meta-analysis
title_sort association of alopecia areata with sensorineural hearing loss: a systematic review and meta-analysis
topic Systematic Review and Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407832/
https://www.ncbi.nlm.nih.gov/pubmed/37094565
http://dx.doi.org/10.1159/000530784
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