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Application of pyroptosis in tumor research (Review)
As a potent clinical strategy, cancer therapy has sparked an academic boom over the past few years. Immune checkpoint inhibitors (ICIs) have been demonstrated to be highly successful. These achievements have progressed cancer treatment and have made an indelible mark on cancer. However, the inherent...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407856/ https://www.ncbi.nlm.nih.gov/pubmed/37559585 http://dx.doi.org/10.3892/ol.2023.13962 |
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author | Tan, Jianing Zhuo, Ziliang Si, Yu |
author_facet | Tan, Jianing Zhuo, Ziliang Si, Yu |
author_sort | Tan, Jianing |
collection | PubMed |
description | As a potent clinical strategy, cancer therapy has sparked an academic boom over the past few years. Immune checkpoint inhibitors (ICIs) have been demonstrated to be highly successful. These achievements have progressed cancer treatment and have made an indelible mark on cancer. However, the inherent complexity of cancer means that only part of the population can benefit from this treatment. Pyroptosis is a new suicidal cellular mechanism that induces inflammation by releasing immunogenic cellular components. Inflammatory signaling cascades mediated by pyroptosis commonly inspire numerous cell lysis in immune diseases. Contrariwise, this consequence may be a promising target in cancer research. Therefore, the present study briefly described programmed cell death processes and their potential roles in cancer. Because of the rapid development of bioengineering in cancer, the present study also examined the associated scaffolding available for cancer, highlighting advances in tumor engineering approaches. Ultimately, an improved understanding of pyroptosis and tumor scaffolding might shed light on a combination that can be manipulated for therapeutic purposes. |
format | Online Article Text |
id | pubmed-10407856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-104078562023-08-09 Application of pyroptosis in tumor research (Review) Tan, Jianing Zhuo, Ziliang Si, Yu Oncol Lett Review As a potent clinical strategy, cancer therapy has sparked an academic boom over the past few years. Immune checkpoint inhibitors (ICIs) have been demonstrated to be highly successful. These achievements have progressed cancer treatment and have made an indelible mark on cancer. However, the inherent complexity of cancer means that only part of the population can benefit from this treatment. Pyroptosis is a new suicidal cellular mechanism that induces inflammation by releasing immunogenic cellular components. Inflammatory signaling cascades mediated by pyroptosis commonly inspire numerous cell lysis in immune diseases. Contrariwise, this consequence may be a promising target in cancer research. Therefore, the present study briefly described programmed cell death processes and their potential roles in cancer. Because of the rapid development of bioengineering in cancer, the present study also examined the associated scaffolding available for cancer, highlighting advances in tumor engineering approaches. Ultimately, an improved understanding of pyroptosis and tumor scaffolding might shed light on a combination that can be manipulated for therapeutic purposes. D.A. Spandidos 2023-07-18 /pmc/articles/PMC10407856/ /pubmed/37559585 http://dx.doi.org/10.3892/ol.2023.13962 Text en Copyright: © Tan et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Tan, Jianing Zhuo, Ziliang Si, Yu Application of pyroptosis in tumor research (Review) |
title | Application of pyroptosis in tumor research (Review) |
title_full | Application of pyroptosis in tumor research (Review) |
title_fullStr | Application of pyroptosis in tumor research (Review) |
title_full_unstemmed | Application of pyroptosis in tumor research (Review) |
title_short | Application of pyroptosis in tumor research (Review) |
title_sort | application of pyroptosis in tumor research (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407856/ https://www.ncbi.nlm.nih.gov/pubmed/37559585 http://dx.doi.org/10.3892/ol.2023.13962 |
work_keys_str_mv | AT tanjianing applicationofpyroptosisintumorresearchreview AT zhuoziliang applicationofpyroptosisintumorresearchreview AT siyu applicationofpyroptosisintumorresearchreview |