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Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature

INTRODUCTION: Testicular cancer is the most frequent solid tumor in young people. Most germ cell tumors of the testis, with the exception of vitelline tumors and teratomas in children, and spermatocytic seminoma in the elderly, derive from a common precursor. This precursor, initially described as c...

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Autores principales: Jdaini, Ahmed, El Moudane, Anouar, El Farhaoui, Hammou, Miry, Nadir, Bennani, Amal, Barki, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407882/
https://www.ncbi.nlm.nih.gov/pubmed/37542883
http://dx.doi.org/10.1016/j.ijscr.2023.108609
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author Jdaini, Ahmed
El Moudane, Anouar
El Farhaoui, Hammou
Miry, Nadir
Bennani, Amal
Barki, Ali
author_facet Jdaini, Ahmed
El Moudane, Anouar
El Farhaoui, Hammou
Miry, Nadir
Bennani, Amal
Barki, Ali
author_sort Jdaini, Ahmed
collection PubMed
description INTRODUCTION: Testicular cancer is the most frequent solid tumor in young people. Most germ cell tumors of the testis, with the exception of vitelline tumors and teratomas in children, and spermatocytic seminoma in the elderly, derive from a common precursor. This precursor, initially described as carcinoma in situ (CIS), is now referred to as intratubular Germinal Cell Neoplasia (ITGCN). CASE PRESENTATION: We report the case of a 37-year-old man with intratubular Germinal Cell Neoplasia (ITGCN) on a testis already treated for cryptorchidism in a context of infertility. We proposed active surveillance, but the patient preferred radiotherapy. DISCUSSION: The origin of ITGCN is still not fully understood. The detection of ITGN is often incidental since it typically does not present with noticeable symptoms, and clinical examination may appear normal. The standard treatment for ITGCN is scrotal radiotherapy. CONCLUSION: The standard treatment for ITGCN is scrotal radiotherapy. However, for patients who desire to preserve fertility, regular observation may be considered as an alternative.
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spelling pubmed-104078822023-08-09 Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature Jdaini, Ahmed El Moudane, Anouar El Farhaoui, Hammou Miry, Nadir Bennani, Amal Barki, Ali Int J Surg Case Rep Case Report INTRODUCTION: Testicular cancer is the most frequent solid tumor in young people. Most germ cell tumors of the testis, with the exception of vitelline tumors and teratomas in children, and spermatocytic seminoma in the elderly, derive from a common precursor. This precursor, initially described as carcinoma in situ (CIS), is now referred to as intratubular Germinal Cell Neoplasia (ITGCN). CASE PRESENTATION: We report the case of a 37-year-old man with intratubular Germinal Cell Neoplasia (ITGCN) on a testis already treated for cryptorchidism in a context of infertility. We proposed active surveillance, but the patient preferred radiotherapy. DISCUSSION: The origin of ITGCN is still not fully understood. The detection of ITGN is often incidental since it typically does not present with noticeable symptoms, and clinical examination may appear normal. The standard treatment for ITGCN is scrotal radiotherapy. CONCLUSION: The standard treatment for ITGCN is scrotal radiotherapy. However, for patients who desire to preserve fertility, regular observation may be considered as an alternative. Elsevier 2023-08-02 /pmc/articles/PMC10407882/ /pubmed/37542883 http://dx.doi.org/10.1016/j.ijscr.2023.108609 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jdaini, Ahmed
El Moudane, Anouar
El Farhaoui, Hammou
Miry, Nadir
Bennani, Amal
Barki, Ali
Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature
title Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature
title_full Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature
title_fullStr Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature
title_full_unstemmed Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature
title_short Infertility revealing intratubular germinal cell neoplasia of the testis: Case report and review of the literature
title_sort infertility revealing intratubular germinal cell neoplasia of the testis: case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407882/
https://www.ncbi.nlm.nih.gov/pubmed/37542883
http://dx.doi.org/10.1016/j.ijscr.2023.108609
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