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Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [(18)F]UCB-H PET imaging

OBJECTIVE: In preclinical research, the use of [(18)F]Fluorodesoxyglucose (FDG) as a biomarker for neurodegeneration may induce bias due to enhanced glucose uptake by immune cells. In this study, we sought to investigate synaptic vesicle glycoprotein 2A (SV2A) PET with [(18)F]UCB-H as an alternative...

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Detalles Bibliográficos
Autores principales:	Vogler, Letizia, Ballweg, Anna, Bohr, Bernd, Briel, Nils, Wind, Karin, Antons, Melissa, Kunze, Lea H., Gnörich, Johannes, Lindner, Simon, Gildehaus, Franz-Josef, Baumann, Karlheinz, Bartenstein, Peter, Boening, Guido, Ziegler, Sibylle I., Levin, Johannes, Zwergal, Andreas, Höglinger, Günter U., Herms, Jochen, Brendel, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407951/ https://www.ncbi.nlm.nih.gov/pubmed/37541098 http://dx.doi.org/10.1016/j.nicl.2023.103484

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