Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC development. We demonstrate that fructose triggers KHK and in...

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Detalles Bibliográficos
Autores principales: Guccini, Ilaria, Tang, Guanghui, To, Trang Thuy, Di Rito, Laura, Le Blanc, Solange, Strobel, Oliver, D’Ambrosio, Mariantonietta, Pasquini, Emiliano, Bolis, Marco, Silva, Pamuditha, Kabakci, Hasan Ali, Godbersen, Svenja, Alimonti, Andrea, Schwank, Gerald, Stoffel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
https://www.ncbi.nlm.nih.gov/pubmed/37559908
http://dx.doi.org/10.1016/j.isci.2023.107368

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