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A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response

Norrin (NDP) and WNT7A/B induce and maintain the blood-brain and blood-retina barrier (BBB, BRB) by stimulating the Frizzled4-LDL receptor related protein 5/6 (FZD4-LRP5/6) complex to induce beta-catenin-dependent signaling in endothelial cells (ECs). Recently developed agonists for the FZD4-LRP5 co...

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Detalles Bibliográficos
Autores principales:	Zhang, Lingling, Abedin, Md., Jo, Ha-Neul, Levey, Jacklyn, Dinh, Quynh Chau, Chen, Zhe, Angers, Stephane, Junge, Harald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407957/ https://www.ncbi.nlm.nih.gov/pubmed/37559903 http://dx.doi.org/10.1016/j.isci.2023.107415

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