Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells

BACKGROUND: The prion-like propagation of tau in neurodegenerative disorders implies that misfolded pathological tau can recruit the normal protein and template its aggregation. Here, we report the methods for the development of sensitive biosensor cell lines for the detection of tau seeding activit...

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Detalles Bibliográficos
Autores principales: Lathuiliere, Aurelien, Jo, Youhwa, Perbet, Romain, Donahue, Cameron, Commins, Caitlin, Quittot, Noé, Fan, Zhanyun, Bennett, Rachel E., Hyman, Bradley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408046/
https://www.ncbi.nlm.nih.gov/pubmed/37553663
http://dx.doi.org/10.1186/s13024-023-00643-2

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