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A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
BACKGROUND: Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78) is increased on the surface of cancer cells. Kringle 5, a cell apoptosis agent...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408047/ https://www.ncbi.nlm.nih.gov/pubmed/37553635 http://dx.doi.org/10.1186/s12860-023-00484-3 |
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author | Khater, Ibrahim Nassar, Aaya |
author_facet | Khater, Ibrahim Nassar, Aaya |
author_sort | Khater, Ibrahim |
collection | PubMed |
description | BACKGROUND: Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78) is increased on the surface of cancer cells. Kringle 5, a cell apoptosis agent, is bound to GRP78 to induce cancer cell apoptosis. Kringle 5 was docked to GRP78 using ClusPro 2.0. The interaction between Kringle 5 and GRP78 was investigated. RESULTS: The interacting amino acids were found to be localized in three areas of Kringle 5. The proposed peptide is made up of secondary structure amino acids that contain Kringle 5 interaction residues. The 3D structure of the peptide model amino acids was created using the PEP-FOLD3 web tool. CONCLUSIONS: The proposed peptide completely binds to the GRP78 binding site on the Kringle 5, signaling that it might be effective in the apoptosis of cancer cells. |
format | Online Article Text |
id | pubmed-10408047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104080472023-08-09 A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 Khater, Ibrahim Nassar, Aaya BMC Mol Cell Biol Research BACKGROUND: Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78) is increased on the surface of cancer cells. Kringle 5, a cell apoptosis agent, is bound to GRP78 to induce cancer cell apoptosis. Kringle 5 was docked to GRP78 using ClusPro 2.0. The interaction between Kringle 5 and GRP78 was investigated. RESULTS: The interacting amino acids were found to be localized in three areas of Kringle 5. The proposed peptide is made up of secondary structure amino acids that contain Kringle 5 interaction residues. The 3D structure of the peptide model amino acids was created using the PEP-FOLD3 web tool. CONCLUSIONS: The proposed peptide completely binds to the GRP78 binding site on the Kringle 5, signaling that it might be effective in the apoptosis of cancer cells. BioMed Central 2023-08-08 /pmc/articles/PMC10408047/ /pubmed/37553635 http://dx.doi.org/10.1186/s12860-023-00484-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Khater, Ibrahim Nassar, Aaya A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 |
title | A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 |
title_full | A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 |
title_fullStr | A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 |
title_full_unstemmed | A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 |
title_short | A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78 |
title_sort | computational peptide model induces cancer cells’ apoptosis by docking kringle 5 to grp78 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408047/ https://www.ncbi.nlm.nih.gov/pubmed/37553635 http://dx.doi.org/10.1186/s12860-023-00484-3 |
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