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Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

BACKGROUND: Sepsis is characterized as an insulin resistant state. However, the effects of sepsis on insulin’s signal transduction pathway are unknown. The molecular activity driving insulin signaling is controlled by tyrosine phosphorylation of the insulin receptor β-subunit (IRβ) and of insulin re...

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Detalles Bibliográficos
Autores principales:	Mathew, Deepa, Barillas-Cerritos, Julia, Nedeljkovic-Kurepa, Ana, Abraham, Mabel, Taylor, Matthew D., Deutschman, Clifford S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408057/ https://www.ncbi.nlm.nih.gov/pubmed/37550630 http://dx.doi.org/10.1186/s10020-023-00703-9

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