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Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

BACKGROUND: Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX levels are directly correlated with stage and grade in several human cancers....

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Detalles Bibliográficos
Autores principales:	Centonze, Matteo, Di Conza, Giusy, Lahn, Michael, Fabregat, Isabel, Dituri, Francesco, Gigante, Isabella, Serino, Grazia, Scialpi, Rosanna, Carrieri, Livianna, Negro, Roberto, Pizzuto, Elena, Giannelli, Gianluigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408149/ https://www.ncbi.nlm.nih.gov/pubmed/37550785 http://dx.doi.org/10.1186/s13046-023-02780-4

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