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Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii
Apicomplexan parasites are a group of protists that cause disease in humans and include pathogens like Plasmodium spp., the causative agent of malaria, and Toxoplasma gondii, the etiological agent of toxoplasmosis and one of the most ubiquitous human parasites in the world. Membrane contact sites (M...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408353/ https://www.ncbi.nlm.nih.gov/pubmed/37560622 http://dx.doi.org/10.1177/25152564231189064 |
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author | Huet, Diego Moreno, Silvia N. J. |
author_facet | Huet, Diego Moreno, Silvia N. J. |
author_sort | Huet, Diego |
collection | PubMed |
description | Apicomplexan parasites are a group of protists that cause disease in humans and include pathogens like Plasmodium spp., the causative agent of malaria, and Toxoplasma gondii, the etiological agent of toxoplasmosis and one of the most ubiquitous human parasites in the world. Membrane contact sites (MCSs) are widespread structures within eukaryotic cells but their characterization in apicomplexan parasites is only in its very beginnings. Basic biological features of the T. gondii parasitic cycle support numerous organellar interactions, including the transfer of Ca(2+) and metabolites between different compartments. In T. gondii, Ca(2+) signals precede a series of interrelated molecular processes occurring in a coordinated manner that culminate in the stimulation of key steps of the parasite life cycle. Calcium transfer from the endoplasmic reticulum to other organelles via MCSs would explain the precision, speed, and efficiency that is needed during the lytic cycle of T. gondii. In this short review, we discuss the implications of these structures in cellular signaling, with an emphasis on their potential role in Ca(2+) signaling. |
format | Online Article Text |
id | pubmed-10408353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-104083532023-08-09 Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii Huet, Diego Moreno, Silvia N. J. Contact (Thousand Oaks) Membrane Contact sites as hubs for Ca2+ signaling Apicomplexan parasites are a group of protists that cause disease in humans and include pathogens like Plasmodium spp., the causative agent of malaria, and Toxoplasma gondii, the etiological agent of toxoplasmosis and one of the most ubiquitous human parasites in the world. Membrane contact sites (MCSs) are widespread structures within eukaryotic cells but their characterization in apicomplexan parasites is only in its very beginnings. Basic biological features of the T. gondii parasitic cycle support numerous organellar interactions, including the transfer of Ca(2+) and metabolites between different compartments. In T. gondii, Ca(2+) signals precede a series of interrelated molecular processes occurring in a coordinated manner that culminate in the stimulation of key steps of the parasite life cycle. Calcium transfer from the endoplasmic reticulum to other organelles via MCSs would explain the precision, speed, and efficiency that is needed during the lytic cycle of T. gondii. In this short review, we discuss the implications of these structures in cellular signaling, with an emphasis on their potential role in Ca(2+) signaling. SAGE Publications 2023-08-06 /pmc/articles/PMC10408353/ /pubmed/37560622 http://dx.doi.org/10.1177/25152564231189064 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Membrane Contact sites as hubs for Ca2+ signaling Huet, Diego Moreno, Silvia N. J. Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii |
title | Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii |
title_full | Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii |
title_fullStr | Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii |
title_full_unstemmed | Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii |
title_short | Interorganellar Communication Through Membrane Contact Sites in Toxoplasma Gondii |
title_sort | interorganellar communication through membrane contact sites in toxoplasma gondii |
topic | Membrane Contact sites as hubs for Ca2+ signaling |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408353/ https://www.ncbi.nlm.nih.gov/pubmed/37560622 http://dx.doi.org/10.1177/25152564231189064 |
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