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Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report

We present the first documented case of metastatic melanoma to the orbit with dedifferentiation. A patient with a history of melanoma of the lip and other poorly differentiated carcinomas presented with both a sub-brow and an intraorbital mass. Radiographically and intraoperatively, the sub-brow mas...

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Autores principales: Rana, Harkaran S, Dertinger, Jake E, Clabeaux, Carson, Makepeace, Nicole, Lewis, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408357/
https://www.ncbi.nlm.nih.gov/pubmed/37559849
http://dx.doi.org/10.7759/cureus.41591
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author Rana, Harkaran S
Dertinger, Jake E
Clabeaux, Carson
Makepeace, Nicole
Lewis, Jason
author_facet Rana, Harkaran S
Dertinger, Jake E
Clabeaux, Carson
Makepeace, Nicole
Lewis, Jason
author_sort Rana, Harkaran S
collection PubMed
description We present the first documented case of metastatic melanoma to the orbit with dedifferentiation. A patient with a history of melanoma of the lip and other poorly differentiated carcinomas presented with both a sub-brow and an intraorbital mass. Radiographically and intraoperatively, the sub-brow mass communicated with the intraorbital mass via perineural spread along the supraorbital nerve. Histopathology confirmed the diagnosis of melanoma based on the melanocytic markers, SOX-10 and Melan-A; dedifferentiation was demonstrated within the orbital tumor. Two weeks following surgical debulking, the intraorbital mass returned to its full size. Local radiotherapy and immunotherapy were performed, which initially led to a dramatic improvement; however, the patient succumbed to his systemic metastases six months later. Dedifferentiation serves as a prognostic indicator and should be considered in patients when histopathology does not lead to a definitive diagnosis.
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spelling pubmed-104083572023-08-09 Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report Rana, Harkaran S Dertinger, Jake E Clabeaux, Carson Makepeace, Nicole Lewis, Jason Cureus Ophthalmology We present the first documented case of metastatic melanoma to the orbit with dedifferentiation. A patient with a history of melanoma of the lip and other poorly differentiated carcinomas presented with both a sub-brow and an intraorbital mass. Radiographically and intraoperatively, the sub-brow mass communicated with the intraorbital mass via perineural spread along the supraorbital nerve. Histopathology confirmed the diagnosis of melanoma based on the melanocytic markers, SOX-10 and Melan-A; dedifferentiation was demonstrated within the orbital tumor. Two weeks following surgical debulking, the intraorbital mass returned to its full size. Local radiotherapy and immunotherapy were performed, which initially led to a dramatic improvement; however, the patient succumbed to his systemic metastases six months later. Dedifferentiation serves as a prognostic indicator and should be considered in patients when histopathology does not lead to a definitive diagnosis. Cureus 2023-07-09 /pmc/articles/PMC10408357/ /pubmed/37559849 http://dx.doi.org/10.7759/cureus.41591 Text en Copyright © 2023, Rana et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Ophthalmology
Rana, Harkaran S
Dertinger, Jake E
Clabeaux, Carson
Makepeace, Nicole
Lewis, Jason
Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report
title Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report
title_full Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report
title_fullStr Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report
title_full_unstemmed Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report
title_short Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report
title_sort metastatic melanoma to the orbit with dedifferentiation: a case report
topic Ophthalmology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408357/
https://www.ncbi.nlm.nih.gov/pubmed/37559849
http://dx.doi.org/10.7759/cureus.41591
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