The Antinociceptive Activity of (E)-3-(thiophen-2-yl)-N-(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)-N-methyl-N-(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor

The primary objective of this study was to characterize the pharmacological and behavioral activity of 2 novel compounds, DM497 [(E)-3-(thiophen-2-yl)-N-(p-tolyl)acrylamide] and DM490 [(E)-3-(furan-2-yl)-N-methyl-N-(p-tolyl)acrylamide], structural derivatives of PAM-2, a positive allosteric modulato...

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Detalles Bibliográficos
Autores principales: Arias, Hugo R., Tae, Han-Shen, Micheli, Laura, Yousuf, Arsalan, Manetti, Dina, Romanelli, Maria Novella, Ghelardini, Carla, Adams, David J., Di Cesare Mannelli, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
38
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408732/
https://www.ncbi.nlm.nih.gov/pubmed/37058425
http://dx.doi.org/10.1213/ANE.0000000000006461

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