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Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining

In recent years, the prevalence of T2DM has been increasing annually, in particular, the personal and socioeconomic burden caused by multiple complications has become increasingly serious. This study aimed to screen out the high-risk complication combination of T2DM through various data mining metho...

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Autores principales: Luo, Xin, Sun, Jijia, Pan, Hong, Zhou, Dian, Huang, Ping, Tang, Jingjing, Shi, Rong, Ye, Hong, Zhao, Ying, Zhang, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409378/
https://www.ncbi.nlm.nih.gov/pubmed/37552706
http://dx.doi.org/10.1371/journal.pone.0289749
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author Luo, Xin
Sun, Jijia
Pan, Hong
Zhou, Dian
Huang, Ping
Tang, Jingjing
Shi, Rong
Ye, Hong
Zhao, Ying
Zhang, An
author_facet Luo, Xin
Sun, Jijia
Pan, Hong
Zhou, Dian
Huang, Ping
Tang, Jingjing
Shi, Rong
Ye, Hong
Zhao, Ying
Zhang, An
author_sort Luo, Xin
collection PubMed
description In recent years, the prevalence of T2DM has been increasing annually, in particular, the personal and socioeconomic burden caused by multiple complications has become increasingly serious. This study aimed to screen out the high-risk complication combination of T2DM through various data mining methods, establish and evaluate a risk prediction model of the complication combination in patients with T2DM. Questionnaire surveys, physical examinations, and biochemical tests were conducted on 4,937 patients with T2DM, and 810 cases of sample data with complications were retained. The high-risk complication combination was screened by association rules based on the Apriori algorithm. Risk factors were screened using the LASSO regression model, random forest model, and support vector machine. A risk prediction model was established using logistic regression analysis, and a dynamic nomogram was constructed. Receiver operating characteristic (ROC) curves, harrell’s concordance index (C-Index), calibration curves, decision curve analysis (DCA), and internal validation were used to evaluate the differentiation, calibration, and clinical applicability of the models. This study found that patients with T2DM had a high-risk combination of lower extremity vasculopathy, diabetic foot, and diabetic retinopathy. Based on this, body mass index, diastolic blood pressure, total cholesterol, triglyceride, 2-hour postprandial blood glucose and blood urea nitrogen levels were screened and used for the modeling analysis. The area under the ROC curves of the internal and external validations were 0.768 (95% CI, 0.744−0.792) and 0.745 (95% CI, 0.669−0.820), respectively, and the C-index and AUC value were consistent. The calibration plots showed good calibration, and the risk threshold for DCA was 30–54%. In this study, we developed and evaluated a predictive model for the development of a high-risk complication combination while uncovering the pattern of complications in patients with T2DM. This model has a practical guiding effect on the health management of patients with T2DM in community settings.
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spelling pubmed-104093782023-08-09 Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining Luo, Xin Sun, Jijia Pan, Hong Zhou, Dian Huang, Ping Tang, Jingjing Shi, Rong Ye, Hong Zhao, Ying Zhang, An PLoS One Research Article In recent years, the prevalence of T2DM has been increasing annually, in particular, the personal and socioeconomic burden caused by multiple complications has become increasingly serious. This study aimed to screen out the high-risk complication combination of T2DM through various data mining methods, establish and evaluate a risk prediction model of the complication combination in patients with T2DM. Questionnaire surveys, physical examinations, and biochemical tests were conducted on 4,937 patients with T2DM, and 810 cases of sample data with complications were retained. The high-risk complication combination was screened by association rules based on the Apriori algorithm. Risk factors were screened using the LASSO regression model, random forest model, and support vector machine. A risk prediction model was established using logistic regression analysis, and a dynamic nomogram was constructed. Receiver operating characteristic (ROC) curves, harrell’s concordance index (C-Index), calibration curves, decision curve analysis (DCA), and internal validation were used to evaluate the differentiation, calibration, and clinical applicability of the models. This study found that patients with T2DM had a high-risk combination of lower extremity vasculopathy, diabetic foot, and diabetic retinopathy. Based on this, body mass index, diastolic blood pressure, total cholesterol, triglyceride, 2-hour postprandial blood glucose and blood urea nitrogen levels were screened and used for the modeling analysis. The area under the ROC curves of the internal and external validations were 0.768 (95% CI, 0.744−0.792) and 0.745 (95% CI, 0.669−0.820), respectively, and the C-index and AUC value were consistent. The calibration plots showed good calibration, and the risk threshold for DCA was 30–54%. In this study, we developed and evaluated a predictive model for the development of a high-risk complication combination while uncovering the pattern of complications in patients with T2DM. This model has a practical guiding effect on the health management of patients with T2DM in community settings. Public Library of Science 2023-08-08 /pmc/articles/PMC10409378/ /pubmed/37552706 http://dx.doi.org/10.1371/journal.pone.0289749 Text en © 2023 Luo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Luo, Xin
Sun, Jijia
Pan, Hong
Zhou, Dian
Huang, Ping
Tang, Jingjing
Shi, Rong
Ye, Hong
Zhao, Ying
Zhang, An
Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
title Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
title_full Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
title_fullStr Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
title_full_unstemmed Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
title_short Establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
title_sort establishment and health management application of a prediction model for high-risk complication combination of type 2 diabetes mellitus based on data mining
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409378/
https://www.ncbi.nlm.nih.gov/pubmed/37552706
http://dx.doi.org/10.1371/journal.pone.0289749
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