T-cell priming transcriptomic markers: implications of immunome heterogeneity for precision immunotherapy

Immune checkpoint blockade is effective for only a subset of cancers. Targeting T-cell priming markers (TPMs) may enhance activity, but proper application of these agents in the clinic is challenging due to immune complexity and heterogeneity. We interrogated transcriptomics of 15 TPMs (CD137, CD27,...

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Detalles Bibliográficos
Autores principales: Miyashita, Hirotaka, Kurzrock, Razelle, Bevins, Nicholas J., Thangathurai, Kartheeswaran, Lee, Suzanna, Pabla, Sarabjot, Nesline, Mary, Glenn, Sean T., Conroy, Jeffrey M., DePietro, Paul, Rubin, Eitan, Sicklick, Jason K., Kato, Shumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409760/
https://www.ncbi.nlm.nih.gov/pubmed/37553332
http://dx.doi.org/10.1038/s41525-023-00359-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409760/
https://www.ncbi.nlm.nih.gov/pubmed/37553332
http://dx.doi.org/10.1038/s41525-023-00359-8

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