Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn(2+) uptake into the Golgi apparatus

Zinc ions (Zn(2+)) are vital to most cells, with the intracellular concentrations of Zn(2+) being tightly regulated by multiple zinc transporters located at the plasma and organelle membranes. We herein present the 2.2-3.1 Å-resolution cryo-EM structures of a Golgi-localized human Zn(2+)/H(+) antipo...

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Detalles Bibliográficos
Autores principales: Bui, Han Ba, Watanabe, Satoshi, Nomura, Norimichi, Liu, Kehong, Uemura, Tomoko, Inoue, Michio, Tsutsumi, Akihisa, Fujita, Hiroyuki, Kinoshita, Kengo, Kato, Yukinari, Iwata, So, Kikkawa, Masahide, Inaba, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409766/
https://www.ncbi.nlm.nih.gov/pubmed/37553324
http://dx.doi.org/10.1038/s41467-023-40521-5

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