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Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation

Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic resonance signal by several orders of magnitude and has enabled real-time metabolic imaging in humans. However, the translation of hyperpolarization technology into routine use in laboratories and medical centers i...

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Autores principales: Ellermann, Frowin, Sirbu, Aidan, Brahms, Arne, Assaf, Charbel, Herges, Rainer, Hövener, Jan-Bernd, Pravdivtsev, Andrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409769/
https://www.ncbi.nlm.nih.gov/pubmed/37553405
http://dx.doi.org/10.1038/s41467-023-40539-9
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author Ellermann, Frowin
Sirbu, Aidan
Brahms, Arne
Assaf, Charbel
Herges, Rainer
Hövener, Jan-Bernd
Pravdivtsev, Andrey N.
author_facet Ellermann, Frowin
Sirbu, Aidan
Brahms, Arne
Assaf, Charbel
Herges, Rainer
Hövener, Jan-Bernd
Pravdivtsev, Andrey N.
author_sort Ellermann, Frowin
collection PubMed
description Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic resonance signal by several orders of magnitude and has enabled real-time metabolic imaging in humans. However, the translation of hyperpolarization technology into routine use in laboratories and medical centers is hampered by the lack of portable, cost-effective polarizers that are not commercially available. Here, we present a portable, automated polarizer based on parahydrogen-induced hyperpolarization (PHIP) at an intermediate magnetic field of 0.5 T (achieved by permanent magnets). With a footprint of 1 m(2), we demonstrate semi-continuous, fully automated (1)H hyperpolarization of ethyl acetate-d6 and ethyl pyruvate-d6 to P = 14.4% and 16.2%, respectively, and a (13)C polarization of 1-(13)C-ethyl pyruvate-d6 of P = 7%. The duty cycle for preparing a dose is no more than 1 min. To reveal the full potential of (1)H hyperpolarization in an inhomogeneous magnetic field, we convert the anti-phase PHIP signals into in-phase peaks, thereby increasing the SNR by a factor of 5. Using a spin-echo approach allowed us to observe the evolution of spin order distribution in real time while conserving the expensive reagents for reaction monitoring, imaging and potential in vivo usage. This compact polarizer will allow us to pursue the translation of hyperpolarized MRI towards in vivo applications further.
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spelling pubmed-104097692023-08-10 Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation Ellermann, Frowin Sirbu, Aidan Brahms, Arne Assaf, Charbel Herges, Rainer Hövener, Jan-Bernd Pravdivtsev, Andrey N. Nat Commun Article Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic resonance signal by several orders of magnitude and has enabled real-time metabolic imaging in humans. However, the translation of hyperpolarization technology into routine use in laboratories and medical centers is hampered by the lack of portable, cost-effective polarizers that are not commercially available. Here, we present a portable, automated polarizer based on parahydrogen-induced hyperpolarization (PHIP) at an intermediate magnetic field of 0.5 T (achieved by permanent magnets). With a footprint of 1 m(2), we demonstrate semi-continuous, fully automated (1)H hyperpolarization of ethyl acetate-d6 and ethyl pyruvate-d6 to P = 14.4% and 16.2%, respectively, and a (13)C polarization of 1-(13)C-ethyl pyruvate-d6 of P = 7%. The duty cycle for preparing a dose is no more than 1 min. To reveal the full potential of (1)H hyperpolarization in an inhomogeneous magnetic field, we convert the anti-phase PHIP signals into in-phase peaks, thereby increasing the SNR by a factor of 5. Using a spin-echo approach allowed us to observe the evolution of spin order distribution in real time while conserving the expensive reagents for reaction monitoring, imaging and potential in vivo usage. This compact polarizer will allow us to pursue the translation of hyperpolarized MRI towards in vivo applications further. Nature Publishing Group UK 2023-08-08 /pmc/articles/PMC10409769/ /pubmed/37553405 http://dx.doi.org/10.1038/s41467-023-40539-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ellermann, Frowin
Sirbu, Aidan
Brahms, Arne
Assaf, Charbel
Herges, Rainer
Hövener, Jan-Bernd
Pravdivtsev, Andrey N.
Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
title Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
title_full Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
title_fullStr Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
title_full_unstemmed Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
title_short Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
title_sort spying on parahydrogen-induced polarization transfer using a half-tesla benchtop mri and hyperpolarized imaging enabled by automation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409769/
https://www.ncbi.nlm.nih.gov/pubmed/37553405
http://dx.doi.org/10.1038/s41467-023-40539-9
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