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Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer

ISG15 plays a crucial role in the innate immune response and has been well-studied due to its antiviral activity and regulation of signal transduction, apoptosis, and autophagy. ISG15 is a ubiquitin-like protein that is activated by an E1 enzyme (Uba7) and transferred to a cognate E2 enzyme (UBE2L6)...

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Detalles Bibliográficos
Autores principales:	Afsar, Mohammad, Liu, GuanQun, Jia, Lijia, Ruben, Eliza A., Nayak, Digant, Sayyad, Zuberwasim, Bury, Priscila dos Santos, Cano, Kristin E., Nayak, Anindita, Zhao, Xiang Ru, Shukla, Ankita, Sung, Patrick, Wasmuth, Elizabeth V., Gack, Michaela U., Olsen, Shaun K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409785/ https://www.ncbi.nlm.nih.gov/pubmed/37553340 http://dx.doi.org/10.1038/s41467-023-39780-z

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