Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

While several COVID-19 vaccines have been in use, more effective and durable vaccines are needed to combat the ongoing COVID-19 pandemic. Here, we report highly immunogenic self-assembling SARS-CoV-2 spike-HBsAg nanoparticles displaying a six-proline-stabilized WA1 (wild type, WT) spike S6P on a HBs...

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Detalles Bibliográficos
Autores principales: Liu, Cuiping, Wang, Lingshu, Merriam, Jonah S., Shi, Wei, Yang, Eun Sung, Zhang, Yi, Chen, Man, Kong, Wing-Pui, Cheng, Cheng, Tsybovsky, Yaroslav, Stephens, Tyler, Verardi, Raffaello, Leung, Kwanyee, Stein, Cody, Olia, Adam S., Harris, Darcy R., Choe, Misook, Zhang, Baoshan, Graham, Barney S., Kwong, Peter D., Koup, Richard A., Pegu, Amarendra, Mascola, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409857/
https://www.ncbi.nlm.nih.gov/pubmed/37553406
http://dx.doi.org/10.1038/s41541-023-00707-w

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