The initial age‐associated decline in early T‐cell progenitors reflects fewer pre‐thymic progenitors and altered signals in the bone marrow and thymus microenvironments

Age‐related thymus involution results in decreased T‐cell production, contributing to increased susceptibility to pathogens and reduced vaccine responsiveness. Elucidating mechanisms underlying thymus involution will inform strategies to restore thymopoiesis with age. The thymus is colonized by circ...

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Detalles Bibliográficos
Autores principales: Srinivasan, Jayashree, Vasudev, Anusha, Shasha, Carolyn, Selden, Hilary J., Perez, Encarnacion, LaFleur, Bonnie, Sinari, Shripad A., Krueger, Andreas, Richie, Ellen R., Ehrlich, Lauren I. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410006/
https://www.ncbi.nlm.nih.gov/pubmed/37221658
http://dx.doi.org/10.1111/acel.13870

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