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C-reactive protein: a target for therapy to reduce inflammation

C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single disease state. Circulating CRP levels have been mo...

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Autores principales: Rizo-Téllez, Salma A., Sekheri, Meriem, Filep, János G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410079/
https://www.ncbi.nlm.nih.gov/pubmed/37564640
http://dx.doi.org/10.3389/fimmu.2023.1237729
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author Rizo-Téllez, Salma A.
Sekheri, Meriem
Filep, János G.
author_facet Rizo-Téllez, Salma A.
Sekheri, Meriem
Filep, János G.
author_sort Rizo-Téllez, Salma A.
collection PubMed
description C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single disease state. Circulating CRP levels have been monitored with a varying degree of success to gauge disease severity or to predict disease progression and outcome. Elevations in CRP level have been implicated as a useful marker to identify patients at risk for cardiovascular disease and certain cancers, and to guide therapy in a context-dependent manner. Since even strong associations do not establish causality, the pathogenic role of CRP has often been over-interpreted. CRP functions as an important modulator of host defense against bacterial infection, tissue injury and autoimmunity. CRP exists in conformationally distinct forms, which exhibit distinct functional properties and help explaining the diverse, often contradictory effects attributed to CRP. In particular, dissociation of native pentameric CRP into its subunits, monomeric CRP, unmasks “hidden” pro-inflammatory activities in pentameric CRP. Here, we review recent advances in CRP targeting strategies, therapeutic lowering of circulating CRP level and development of CRP antagonists, and a conformation change inhibitor in particular. We will also discuss their therapeutic potential in mitigating the deleterious actions attributed to CRP under various pathologies, including cardiovascular, pulmonary and autoimmune diseases and cancer.
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spelling pubmed-104100792023-08-10 C-reactive protein: a target for therapy to reduce inflammation Rizo-Téllez, Salma A. Sekheri, Meriem Filep, János G. Front Immunol Immunology C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation. Association of elevations in plasma/serum CRP level with disease state has received considerable attention, even though CRP is not a specific indicator of a single disease state. Circulating CRP levels have been monitored with a varying degree of success to gauge disease severity or to predict disease progression and outcome. Elevations in CRP level have been implicated as a useful marker to identify patients at risk for cardiovascular disease and certain cancers, and to guide therapy in a context-dependent manner. Since even strong associations do not establish causality, the pathogenic role of CRP has often been over-interpreted. CRP functions as an important modulator of host defense against bacterial infection, tissue injury and autoimmunity. CRP exists in conformationally distinct forms, which exhibit distinct functional properties and help explaining the diverse, often contradictory effects attributed to CRP. In particular, dissociation of native pentameric CRP into its subunits, monomeric CRP, unmasks “hidden” pro-inflammatory activities in pentameric CRP. Here, we review recent advances in CRP targeting strategies, therapeutic lowering of circulating CRP level and development of CRP antagonists, and a conformation change inhibitor in particular. We will also discuss their therapeutic potential in mitigating the deleterious actions attributed to CRP under various pathologies, including cardiovascular, pulmonary and autoimmune diseases and cancer. Frontiers Media S.A. 2023-07-26 /pmc/articles/PMC10410079/ /pubmed/37564640 http://dx.doi.org/10.3389/fimmu.2023.1237729 Text en Copyright © 2023 Rizo-Téllez, Sekheri and Filep https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Rizo-Téllez, Salma A.
Sekheri, Meriem
Filep, János G.
C-reactive protein: a target for therapy to reduce inflammation
title C-reactive protein: a target for therapy to reduce inflammation
title_full C-reactive protein: a target for therapy to reduce inflammation
title_fullStr C-reactive protein: a target for therapy to reduce inflammation
title_full_unstemmed C-reactive protein: a target for therapy to reduce inflammation
title_short C-reactive protein: a target for therapy to reduce inflammation
title_sort c-reactive protein: a target for therapy to reduce inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410079/
https://www.ncbi.nlm.nih.gov/pubmed/37564640
http://dx.doi.org/10.3389/fimmu.2023.1237729
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