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Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection

BACKGROUND: Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example, Helicobacter pylori have been suggested in rosacea progression. The present study investigated the rel...

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Autores principales: Aghaei, Maryam, Aghaei, Shahrzad, Behshadnia, Fatemeh, Ghomashlooyan, Mohsen, Khaghani, Armin, Baradaran, Elahe H., Naeini, Farahnaz F., Iraji, Fariba, Shahmoradi, Zabihollah, Hosseini, Sayed M., Hejazi, Seyed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410436/
https://www.ncbi.nlm.nih.gov/pubmed/37564456
http://dx.doi.org/10.4103/abr.abr_236_22
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author Aghaei, Maryam
Aghaei, Shahrzad
Behshadnia, Fatemeh
Ghomashlooyan, Mohsen
Khaghani, Armin
Baradaran, Elahe H.
Naeini, Farahnaz F.
Iraji, Fariba
Shahmoradi, Zabihollah
Hosseini, Sayed M.
Hejazi, Seyed H.
author_facet Aghaei, Maryam
Aghaei, Shahrzad
Behshadnia, Fatemeh
Ghomashlooyan, Mohsen
Khaghani, Armin
Baradaran, Elahe H.
Naeini, Farahnaz F.
Iraji, Fariba
Shahmoradi, Zabihollah
Hosseini, Sayed M.
Hejazi, Seyed H.
author_sort Aghaei, Maryam
collection PubMed
description BACKGROUND: Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example, Helicobacter pylori have been suggested in rosacea progression. The present study investigated the relationship between H. pylori eradication and rosacea patient's improvement. MATERIALS AND METHODS: H. pylori infection was investigated in 60 rosacea patients and 65 sex- and age-matched healthy control through enzyme-linked immunosorbent assay (ELISA) and HpSag tests. After infection confirmation, randomly half of the rosacea patients were treated for H. pylori eradication (test), and others received standard treatment (control). HpSag and ELISA tests were repeated after infection eradication and disease flow was surveyed for 60 days. The groups were compared using the ANOVA (Analysis Of Variance) test at the significant level of P < 0.05. RESULTS: At the baseline, the mean of immunoglobulin G (IgG) (59.27 ± 41.4 RU/mL) and immunoglobulin M (IgM) (11.55 ± 6.1 RU/mL) in rosacea patients was higher than the level of IgG (41.38 ± 54.33 RU/mL) and IgM (8.11 ± 8.91 RU/mL) in healthy control (P < 0.04) and (P < 0.01), respectively. Also, the values for H. pylori infection were positive in all patients and 10 healthy controls. The mean titer of IgM and IgG in the test and control patients groups were different at baseline and after treatment. Furthermore, in the test patients group, the mean of IgG was reduced in active rosacea after treatment, and 63.9% of active patients showed rosacea remission after H. pylori eradication. CONCLUSION: Data suggest the exacerbating role of H. pylori in rosacea, and its eradication along with other therapeutic methods causes rosacea improvement.
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spelling pubmed-104104362023-08-10 Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection Aghaei, Maryam Aghaei, Shahrzad Behshadnia, Fatemeh Ghomashlooyan, Mohsen Khaghani, Armin Baradaran, Elahe H. Naeini, Farahnaz F. Iraji, Fariba Shahmoradi, Zabihollah Hosseini, Sayed M. Hejazi, Seyed H. Adv Biomed Res Original Article BACKGROUND: Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example, Helicobacter pylori have been suggested in rosacea progression. The present study investigated the relationship between H. pylori eradication and rosacea patient's improvement. MATERIALS AND METHODS: H. pylori infection was investigated in 60 rosacea patients and 65 sex- and age-matched healthy control through enzyme-linked immunosorbent assay (ELISA) and HpSag tests. After infection confirmation, randomly half of the rosacea patients were treated for H. pylori eradication (test), and others received standard treatment (control). HpSag and ELISA tests were repeated after infection eradication and disease flow was surveyed for 60 days. The groups were compared using the ANOVA (Analysis Of Variance) test at the significant level of P < 0.05. RESULTS: At the baseline, the mean of immunoglobulin G (IgG) (59.27 ± 41.4 RU/mL) and immunoglobulin M (IgM) (11.55 ± 6.1 RU/mL) in rosacea patients was higher than the level of IgG (41.38 ± 54.33 RU/mL) and IgM (8.11 ± 8.91 RU/mL) in healthy control (P < 0.04) and (P < 0.01), respectively. Also, the values for H. pylori infection were positive in all patients and 10 healthy controls. The mean titer of IgM and IgG in the test and control patients groups were different at baseline and after treatment. Furthermore, in the test patients group, the mean of IgG was reduced in active rosacea after treatment, and 63.9% of active patients showed rosacea remission after H. pylori eradication. CONCLUSION: Data suggest the exacerbating role of H. pylori in rosacea, and its eradication along with other therapeutic methods causes rosacea improvement. Wolters Kluwer - Medknow 2023-06-30 /pmc/articles/PMC10410436/ /pubmed/37564456 http://dx.doi.org/10.4103/abr.abr_236_22 Text en Copyright: © 2023 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Aghaei, Maryam
Aghaei, Shahrzad
Behshadnia, Fatemeh
Ghomashlooyan, Mohsen
Khaghani, Armin
Baradaran, Elahe H.
Naeini, Farahnaz F.
Iraji, Fariba
Shahmoradi, Zabihollah
Hosseini, Sayed M.
Hejazi, Seyed H.
Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection
title Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection
title_full Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection
title_fullStr Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection
title_full_unstemmed Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection
title_short Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection
title_sort association between the treatment of rosacea and eradication of helicobacter pylori infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410436/
https://www.ncbi.nlm.nih.gov/pubmed/37564456
http://dx.doi.org/10.4103/abr.abr_236_22
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