Preclinical PK investigation of a novel IDO1/TDO dual inhibitor—SHR9146 in mouse plasma and tissues by LC-MS/MS

PURPOSE: The aim of the present study was to establish a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for the determination of SHR9146, a novel IDO1/TDO dual inhibitor, in mouse plasma and tissues, and to apply it to investigate the preclinical plasma pharmacokinetics and tissue...

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Detalles Bibliográficos
Autores principales: Xiao, Mei, Zhong, Kan, Guo, Li, Li, Wei, Wang, Xiaoli, Qiu, Zhenjun, Hang, Taijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410440/
https://www.ncbi.nlm.nih.gov/pubmed/37564938
http://dx.doi.org/10.3389/fonc.2023.1191778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410440/
https://www.ncbi.nlm.nih.gov/pubmed/37564938
http://dx.doi.org/10.3389/fonc.2023.1191778

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