Cargando…
Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma
Sebaceous carcinoma (SC) is a rare malignant skin neoplasm derived from the meibomian gland of adnexal epithelium, which is frequently confused with basal cell carcinoma (BCC), exhibiting sebaceous differentiation and commonly found in the head and neck regions. We report a case of penile sebaceous...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410445/ https://www.ncbi.nlm.nih.gov/pubmed/37564939 http://dx.doi.org/10.3389/fonc.2023.1095147 |
_version_ | 1785086460456599552 |
---|---|
author | Fam, Xeng Inn Liu, Chian Yong Md Pauzi, Suria Hayati Rizuana, Iqbal Hussain |
author_facet | Fam, Xeng Inn Liu, Chian Yong Md Pauzi, Suria Hayati Rizuana, Iqbal Hussain |
author_sort | Fam, Xeng Inn |
collection | PubMed |
description | Sebaceous carcinoma (SC) is a rare malignant skin neoplasm derived from the meibomian gland of adnexal epithelium, which is frequently confused with basal cell carcinoma (BCC), exhibiting sebaceous differentiation and commonly found in the head and neck regions. We report a case of penile sebaceous carcinoma, an extremely rare anatomical site for SC. A 68-year-old man presented with a 4-month history of painless, non-healing ulcerated nodules over the left side of the penile shaft. Wedge biopsy showed adenocarcinoma with signet ring differentiation. We proceeded with wide local excision (WLE) of the lesion with the inclusion of the indurated skin and 5 mm of normal margin, followed by primary closure of the scrotal defect and split skin grafting of the penile shaft by using a thigh skin donor. The final histopathological examination revealed sebaceous carcinoma with pagetoid spread. The patient achieved recurrence-free survival without any form of adjuvant therapy after 4 years of follow-up. |
format | Online Article Text |
id | pubmed-10410445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104104452023-08-10 Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma Fam, Xeng Inn Liu, Chian Yong Md Pauzi, Suria Hayati Rizuana, Iqbal Hussain Front Oncol Oncology Sebaceous carcinoma (SC) is a rare malignant skin neoplasm derived from the meibomian gland of adnexal epithelium, which is frequently confused with basal cell carcinoma (BCC), exhibiting sebaceous differentiation and commonly found in the head and neck regions. We report a case of penile sebaceous carcinoma, an extremely rare anatomical site for SC. A 68-year-old man presented with a 4-month history of painless, non-healing ulcerated nodules over the left side of the penile shaft. Wedge biopsy showed adenocarcinoma with signet ring differentiation. We proceeded with wide local excision (WLE) of the lesion with the inclusion of the indurated skin and 5 mm of normal margin, followed by primary closure of the scrotal defect and split skin grafting of the penile shaft by using a thigh skin donor. The final histopathological examination revealed sebaceous carcinoma with pagetoid spread. The patient achieved recurrence-free survival without any form of adjuvant therapy after 4 years of follow-up. Frontiers Media S.A. 2023-07-26 /pmc/articles/PMC10410445/ /pubmed/37564939 http://dx.doi.org/10.3389/fonc.2023.1095147 Text en Copyright © 2023 Fam, Liu, Md Pauzi and Rizuana https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fam, Xeng Inn Liu, Chian Yong Md Pauzi, Suria Hayati Rizuana, Iqbal Hussain Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
title | Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
title_full | Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
title_fullStr | Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
title_full_unstemmed | Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
title_short | Case Report: Optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
title_sort | case report: optimum excision with split skin graft closure in the management of penile sebaceous carcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410445/ https://www.ncbi.nlm.nih.gov/pubmed/37564939 http://dx.doi.org/10.3389/fonc.2023.1095147 |
work_keys_str_mv | AT famxenginn casereportoptimumexcisionwithsplitskingraftclosureinthemanagementofpenilesebaceouscarcinoma AT liuchianyong casereportoptimumexcisionwithsplitskingraftclosureinthemanagementofpenilesebaceouscarcinoma AT mdpauzisuriahayati casereportoptimumexcisionwithsplitskingraftclosureinthemanagementofpenilesebaceouscarcinoma AT rizuanaiqbalhussain casereportoptimumexcisionwithsplitskingraftclosureinthemanagementofpenilesebaceouscarcinoma |