Cargando…

SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates

The diversity of COVID-19 disease in otherwise healthy people, from seemingly asymptomatic infection to severe life-threatening disease, is not clearly understood. We passaged a naturally occurring near-ancestral SARS-CoV-2 variant, capable of infecting wild-type mice, and identified viral genomic m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bader, Stefanie M., Cooney, James P., Sheerin, Dylan, Taiaroa, George, Harty, Leigh, Davidson, Kathryn C., Mackiewicz, Liana, Dayton, Merle, Wilcox, Stephen, Whitehead, Lachlan, Rogers, Kelly L., Georgy, Smitha Rose, Coussens, Anna K., Grimley, Samantha L., Corbin, Vincent, Pitt, Miranda, Coin, Lachlan, Pickering, Raelene, Thomas, Merlin, Allison, Cody C., McAuley, Julie, Purcell, Damian F. J., Doerflinger, Marcel, Pellegrini, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410703/ https://www.ncbi.nlm.nih.gov/pubmed/37523564 http://dx.doi.org/10.1073/pnas.2301689120

Ejemplares similares

The role of MKK4 in T‐cell development and immunity to viral infections
por: Preston, Simon P, et al.
Publicado: (2020)

Programmed cell death: the pathways to severe COVID-19?
por: Bader, Stefanie M., et al.
Publicado: (2022)

Enhanced protein domain discovery using taxonomy
por: Coin, Lachlan, et al.
Publicado: (2004)

cnvOffSeq: detecting intergenic copy number variation using off-target exome sequencing data
por: Bellos, Evangelos, et al.
Publicado: (2014)

Computational analysis and prediction of PE_PGRS proteins using machine learning
por: Li, Fuyi, et al.
Publicado: (2022)

Bioinformatics: living on the edge
por: Bellos, Evangelos, et al.
Publicado: (2012)

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection
por: Chang, Jessie J.-Y., et al.
Publicado: (2021)

cnvHiTSeq: integrative models for high-resolution copy number variation detection and genotyping using population sequencing data
por: Bellos, Evangelos, et al.
Publicado: (2012)

Real-time resolution of short-read assembly graph using ONT long reads
por: Nguyen, Son Hoang, et al.
Publicado: (2021)

Delirium in COVID-19: can we make the unknowns knowns?
por: Wilcox, M. Elizabeth, et al.
Publicado: (2021)

Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions
por: Su, Shu-Yi, et al.
Publicado: (2008)

GtTR: Bayesian estimation of absolute tandem repeat copy number using sequence capture and high throughput sequencing
por: Ganesamoorthy, Devika, et al.
Publicado: (2018)

Simulating the dynamics of targeted capture sequencing with CapSim
por: Cao, Minh Duc, et al.
Publicado: (2018)

Ongoing human chromosome end extension revealed by analysis of BioNano and nanopore data
por: Shao, Haojing, et al.
Publicado: (2018)

sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors
por: Chen, Wenhan, et al.
Publicado: (2017)

Drug resistance prediction for Mycobacterium tuberculosis with reference graphs
por: Hall, Michael B., et al.
Publicado: (2023)

Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing
por: Pitt, Miranda E, et al.
Publicado: (2020)

Oxidative Stress and Inflammation in Cardiovascular Diseases
por: Pickering, Raelene J.
Publicado: (2021)

Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice
por: Arandjelovic, Philip, et al.
Publicado: (2023)

Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infection
por: Sheerin, Dylan, et al.
Publicado: (2022)

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection
por: Preston, Simon P., et al.
Publicado: (2023)

Complete Genome Sequences of Clinical Pandoraea fibrosis Isolates
por: Pitt, Miranda E., et al.
Publicado: (2020)

Complete Genome Sequence of Klebsiella quasipneumoniae subsp. similipneumoniae Strain ATCC 700603
por: Elliott, Alysha G., et al.
Publicado: (2016)

Systematic evaluation of transcriptomic disease risk and diagnostic biomarker overlap between COVID-19 and tuberculosis: a patient-level meta-analysis
por: Sheerin, Dylan, et al.
Publicado: (2020)

Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads
por: Turro, Ernest, et al.
Publicado: (2011)

No evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues
por: Parry, Rhys, et al.
Publicado: (2021)

The Efficacy of Common Household Cleaning Agents for SARS-CoV-2 Infection Control
por: Almeida, Catarina F., et al.
Publicado: (2022)

Manipulative therapy and/or NSAIDs for acute low back pain: design of a randomized controlled trial [ACTRN012605000036617]
por: Hancock, Mark J, et al.
Publicado: (2005)

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
por: Pymm, Phillip, et al.
Publicado: (2021)

Nanopore sequencing as a scalable, cost-effective platform for analyzing polyclonal vector integration sites following clinical T cell therapy
por: Zhang, Ping, et al.
Publicado: (2020)

Evaluation of virucidal activity of residual quaternary ammonium-treated surfaces on SARS-CoV-2
por: Caschera, Alexander G., et al.
Publicado: (2022)

Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae
por: Pitt, Miranda E., et al.
Publicado: (2018)

Conference on Topological Methods in Algebraic Topology
por: McAuley, Louis
Publicado: (1974)

npInv: accurate detection and genotyping of inversions using long read sub-alignment
por: Shao, Haojing, et al.
Publicado: (2018)

A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions
por: Bainomugisa, Arnold, et al.
Publicado: (2018)

Chiron: translating nanopore raw signal directly into nucleotide sequence using deep learning
por: Teng, Haotian, et al.
Publicado: (2018)

Correction to: Chiron: translating nanopore raw signal directly into nucleotide sequence using deep learning
por: Teng, Haotian, et al.
Publicado: (2019)

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo
por: Morrish, Emma, et al.
Publicado: (2020)

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice
por: Doerflinger, Marcel, et al.
Publicado: (2016)

Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection
por: Stutz, Michael D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5sog05g144c98qfj96lu8vf88v