Elevated α5 integrin expression on myeloid cells in motor areas in amyotrophic lateral sclerosis is a therapeutic target

Amyotrophic lateral sclerosis (ALS) is a fatal disease affecting upper and lower motor neurons. Microglia directly interact with motor neurons and participate in the progression of ALS. Single-cell mass cytometry (CyTOF) analysis revealed prominent expression of α5 integrin in microglia and macropha...

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Detalles Bibliográficos
Autores principales: Chiot, Aude, Roemer, Shanu F., Ryner, Lisa, Bogachuk, Alina, Emberley, Katie, Brownell, Dillon, Jimenez, Gisselle A., Leviten, Michael, Woltjer, Randall, Dickson, Dennis W., Steinman, Lawrence, Ajami, Bahareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410747/
https://www.ncbi.nlm.nih.gov/pubmed/37523555
http://dx.doi.org/10.1073/pnas.2306731120

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