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Digestive perianastomotic ulcerations after intestinal resection in children

Digestive perianastomotic ulceration (DPAU) is a rare complication after intestinal resection and anastomosis occurring at or near the anastomosis site. The purpose of this review is to summarize the characteristics of DPAU, including the etiology, diagnosis and differential diagnosis, clinical mani...

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Autores principales: Zhang, Weicheng, Tou, Jinfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410847/
https://www.ncbi.nlm.nih.gov/pubmed/37564926
http://dx.doi.org/10.1136/wjps-2022-000533
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author Zhang, Weicheng
Tou, Jinfa
author_facet Zhang, Weicheng
Tou, Jinfa
author_sort Zhang, Weicheng
collection PubMed
description Digestive perianastomotic ulceration (DPAU) is a rare complication after intestinal resection and anastomosis occurring at or near the anastomosis site. The purpose of this review is to summarize the characteristics of DPAU, including the etiology, diagnosis and differential diagnosis, clinical manifestations, treatment, and future research. All recent literature on DPAU was searched in PubMed, Embase, and Cochrane and then reviewed. The clinical manifestations of DPAU are mainly gastrointestinal symptoms such as bloody stool and chronic anemia. The diagnosis of DPAU is difficult. Specific diseases, such as Crohn’s disease, must be ruled out before a diagnosis can be made. In addition, there are no clear treatment guidelines due to the high degree of heterogeneity in response to drugs and surgery. It is recommended to adjust medication in time and combine various treatment methods. In addition, the mechanism that causes DPAU is not well understood; however, several possible mechanisms have been proposed, such as scar tissue ischemia and underlying diseases. Moreover, there is a high risk of relapses, and a long-term follow-up is necessary. Numerous issues remain to be solved in this area; therefore, more randomized controlled trials and studies should be carried out to further understand this disease.
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spelling pubmed-104108472023-08-10 Digestive perianastomotic ulcerations after intestinal resection in children Zhang, Weicheng Tou, Jinfa World J Pediatr Surg Review Digestive perianastomotic ulceration (DPAU) is a rare complication after intestinal resection and anastomosis occurring at or near the anastomosis site. The purpose of this review is to summarize the characteristics of DPAU, including the etiology, diagnosis and differential diagnosis, clinical manifestations, treatment, and future research. All recent literature on DPAU was searched in PubMed, Embase, and Cochrane and then reviewed. The clinical manifestations of DPAU are mainly gastrointestinal symptoms such as bloody stool and chronic anemia. The diagnosis of DPAU is difficult. Specific diseases, such as Crohn’s disease, must be ruled out before a diagnosis can be made. In addition, there are no clear treatment guidelines due to the high degree of heterogeneity in response to drugs and surgery. It is recommended to adjust medication in time and combine various treatment methods. In addition, the mechanism that causes DPAU is not well understood; however, several possible mechanisms have been proposed, such as scar tissue ischemia and underlying diseases. Moreover, there is a high risk of relapses, and a long-term follow-up is necessary. Numerous issues remain to be solved in this area; therefore, more randomized controlled trials and studies should be carried out to further understand this disease. BMJ Publishing Group 2023-06-26 /pmc/articles/PMC10410847/ /pubmed/37564926 http://dx.doi.org/10.1136/wjps-2022-000533 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Zhang, Weicheng
Tou, Jinfa
Digestive perianastomotic ulcerations after intestinal resection in children
title Digestive perianastomotic ulcerations after intestinal resection in children
title_full Digestive perianastomotic ulcerations after intestinal resection in children
title_fullStr Digestive perianastomotic ulcerations after intestinal resection in children
title_full_unstemmed Digestive perianastomotic ulcerations after intestinal resection in children
title_short Digestive perianastomotic ulcerations after intestinal resection in children
title_sort digestive perianastomotic ulcerations after intestinal resection in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410847/
https://www.ncbi.nlm.nih.gov/pubmed/37564926
http://dx.doi.org/10.1136/wjps-2022-000533
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