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Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits

BACKGROUND: Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting the caliber of the cerebral vessels. It is important to have an effective, contactless way to monitor and assess CVAR in patients with ischemia. METHODS: The adjustment of cere...

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Autores principales: Xu, Jia, Li, Haocheng, Jin, Gui, Zhuang, Wei, Bai, Zelin, Sun, Jian, Chen, Mingsheng, Wang, Feng, Yang, Xu, Qin, Mingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410901/
https://www.ncbi.nlm.nih.gov/pubmed/37559130
http://dx.doi.org/10.1186/s12938-023-01142-7
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author Xu, Jia
Li, Haocheng
Jin, Gui
Zhuang, Wei
Bai, Zelin
Sun, Jian
Chen, Mingsheng
Wang, Feng
Yang, Xu
Qin, Mingxin
author_facet Xu, Jia
Li, Haocheng
Jin, Gui
Zhuang, Wei
Bai, Zelin
Sun, Jian
Chen, Mingsheng
Wang, Feng
Yang, Xu
Qin, Mingxin
author_sort Xu, Jia
collection PubMed
description BACKGROUND: Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting the caliber of the cerebral vessels. It is important to have an effective, contactless way to monitor and assess CVAR in patients with ischemia. METHODS: The adjustment of cerebral blood flow leads to changes in the conductivity of the whole brain. Here, whole-brain conductivity measured by the magnetic induction phase shift method is a valuable alternative to cerebral blood volume for non-contact assessment of CVAR. Therefore, we proposed the correlation coefficient between spontaneous slow oscillations in arterial blood pressure and the corresponding magnetic induction phase shift as a novel index called the conductivity reactivity index (CRx). In comparison with the intracranial pressure reactivity index (PRx), the feasibility of the conductivity reactivity index to assess CVAR in the early phase of cerebral ischemia has been preliminarily confirmed in animal experiments. RESULTS: There was a significant difference in the CRx between the cerebral ischemia group and the control group (p = 0.002). At the same time, there was a significant negative correlation between the CRx and the PRx (r = − 0.642, p = 0.002) after 40 min after ischemia. The Bland–Altman consistency analysis showed that the two indices were linearly related, with a minimal difference and high consistency in the early ischemic period. The sensitivity and specificity of CRx for cerebral ischemia identification were 75% and 20%, respectively, and the area under the ROC curve of CRx was 0.835 (SE = 0.084). CONCLUSION: The animal experimental results preliminarily demonstrated that the CRx can be used to monitor CVAR and identify CVAR injury in early ischemic conditions. The CRx has the potential to be used for contactless, global, bedside, and real-time assessment of CVAR of patients with ischemic stroke.
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spelling pubmed-104109012023-08-10 Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits Xu, Jia Li, Haocheng Jin, Gui Zhuang, Wei Bai, Zelin Sun, Jian Chen, Mingsheng Wang, Feng Yang, Xu Qin, Mingxin Biomed Eng Online Research BACKGROUND: Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting the caliber of the cerebral vessels. It is important to have an effective, contactless way to monitor and assess CVAR in patients with ischemia. METHODS: The adjustment of cerebral blood flow leads to changes in the conductivity of the whole brain. Here, whole-brain conductivity measured by the magnetic induction phase shift method is a valuable alternative to cerebral blood volume for non-contact assessment of CVAR. Therefore, we proposed the correlation coefficient between spontaneous slow oscillations in arterial blood pressure and the corresponding magnetic induction phase shift as a novel index called the conductivity reactivity index (CRx). In comparison with the intracranial pressure reactivity index (PRx), the feasibility of the conductivity reactivity index to assess CVAR in the early phase of cerebral ischemia has been preliminarily confirmed in animal experiments. RESULTS: There was a significant difference in the CRx between the cerebral ischemia group and the control group (p = 0.002). At the same time, there was a significant negative correlation between the CRx and the PRx (r = − 0.642, p = 0.002) after 40 min after ischemia. The Bland–Altman consistency analysis showed that the two indices were linearly related, with a minimal difference and high consistency in the early ischemic period. The sensitivity and specificity of CRx for cerebral ischemia identification were 75% and 20%, respectively, and the area under the ROC curve of CRx was 0.835 (SE = 0.084). CONCLUSION: The animal experimental results preliminarily demonstrated that the CRx can be used to monitor CVAR and identify CVAR injury in early ischemic conditions. The CRx has the potential to be used for contactless, global, bedside, and real-time assessment of CVAR of patients with ischemic stroke. BioMed Central 2023-08-09 /pmc/articles/PMC10410901/ /pubmed/37559130 http://dx.doi.org/10.1186/s12938-023-01142-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Xu, Jia
Li, Haocheng
Jin, Gui
Zhuang, Wei
Bai, Zelin
Sun, Jian
Chen, Mingsheng
Wang, Feng
Yang, Xu
Qin, Mingxin
Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
title Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
title_full Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
title_fullStr Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
title_full_unstemmed Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
title_short Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
title_sort conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410901/
https://www.ncbi.nlm.nih.gov/pubmed/37559130
http://dx.doi.org/10.1186/s12938-023-01142-7
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