SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and pyroptosis of FLS plays a key role in those pathological processes during RA. Th...

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Detalles Bibliográficos
Autores principales: Mao, Xingxing, Wu, Weijie, Nan, Yunyi, Sun, Weiwei, Wang, Youhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410963/
https://www.ncbi.nlm.nih.gov/pubmed/37559090
http://dx.doi.org/10.1186/s13075-023-03136-1

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