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SARS-CoV-2 Infection and Placental Pathology
Placental pathophysiology in SARS-CoV-2 infection can help researchers understand more about the infection and its impact on the maternal/neonatal outcomes. This brief review provides an overview about some aspects of the placental pathology in SARS-CoV-2 infection. In total, 11 papers were included...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411154/ https://www.ncbi.nlm.nih.gov/pubmed/34077991 http://dx.doi.org/10.1055/s-0041-1730291 |
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author | Leal, Caio Ribeiro Vieira Maciel, Rayra Amana Macêdo Corrêa Júnior, Mário Dias |
author_facet | Leal, Caio Ribeiro Vieira Maciel, Rayra Amana Macêdo Corrêa Júnior, Mário Dias |
author_sort | Leal, Caio Ribeiro Vieira |
collection | PubMed |
description | Placental pathophysiology in SARS-CoV-2 infection can help researchers understand more about the infection and its impact on the maternal/neonatal outcomes. This brief review provides an overview about some aspects of the placental pathology in SARS-CoV-2 infection. In total, 11 papers were included. The current literature suggests that there are no specific histopathological characteristics in the placenta related to SARS-CoV-2 infection, but placentas from infected women are more likely to show findings of maternal and/or fetal malperfusion. The most common findings in placentas from infected women were fibrin deposition and intense recruitment of inflammatory infiltrates. The transplacental transmission of this virus is unlikely to occur, probably due to low expression of the receptor for SARS-CoV-2 in placental cell types. Further studies are needed to improve our knowledge about the interaction between the virus and the mother-fetus dyad and the impact on maternal and neonatal/fetal outcomes. |
format | Online Article Text |
id | pubmed-10411154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104111542023-08-10 SARS-CoV-2 Infection and Placental Pathology Leal, Caio Ribeiro Vieira Maciel, Rayra Amana Macêdo Corrêa Júnior, Mário Dias Rev Bras Ginecol Obstet Placental pathophysiology in SARS-CoV-2 infection can help researchers understand more about the infection and its impact on the maternal/neonatal outcomes. This brief review provides an overview about some aspects of the placental pathology in SARS-CoV-2 infection. In total, 11 papers were included. The current literature suggests that there are no specific histopathological characteristics in the placenta related to SARS-CoV-2 infection, but placentas from infected women are more likely to show findings of maternal and/or fetal malperfusion. The most common findings in placentas from infected women were fibrin deposition and intense recruitment of inflammatory infiltrates. The transplacental transmission of this virus is unlikely to occur, probably due to low expression of the receptor for SARS-CoV-2 in placental cell types. Further studies are needed to improve our knowledge about the interaction between the virus and the mother-fetus dyad and the impact on maternal and neonatal/fetal outcomes. Thieme Revinter Publicações Ltda. 2021-06-02 /pmc/articles/PMC10411154/ /pubmed/34077991 http://dx.doi.org/10.1055/s-0041-1730291 Text en Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Leal, Caio Ribeiro Vieira Maciel, Rayra Amana Macêdo Corrêa Júnior, Mário Dias SARS-CoV-2 Infection and Placental Pathology |
title | SARS-CoV-2 Infection and Placental Pathology |
title_full | SARS-CoV-2 Infection and Placental Pathology |
title_fullStr | SARS-CoV-2 Infection and Placental Pathology |
title_full_unstemmed | SARS-CoV-2 Infection and Placental Pathology |
title_short | SARS-CoV-2 Infection and Placental Pathology |
title_sort | sars-cov-2 infection and placental pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411154/ https://www.ncbi.nlm.nih.gov/pubmed/34077991 http://dx.doi.org/10.1055/s-0041-1730291 |
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