The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis
Published data were gathered for a meta-analysis to determine the difference in sperm parameters before and after administration of different types of coronavirus disease 2019 (COVID-19) vaccines, because the reproductive toxicity of COVID-19 vaccines has not yet been evaluated in clinical trials an...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411248/ https://www.ncbi.nlm.nih.gov/pubmed/36510860 http://dx.doi.org/10.4103/aja2022100 |
_version_ | 1785086622983782400 |
---|---|
author | Ma, Yu-Cheng Cheng, Chao Yuan, Chi Xiang, Li-Yuan Wen, Jun Jin, Xi |
author_facet | Ma, Yu-Cheng Cheng, Chao Yuan, Chi Xiang, Li-Yuan Wen, Jun Jin, Xi |
author_sort | Ma, Yu-Cheng |
collection | PubMed |
description | Published data were gathered for a meta-analysis to determine the difference in sperm parameters before and after administration of different types of coronavirus disease 2019 (COVID-19) vaccines, because the reproductive toxicity of COVID-19 vaccines has not yet been evaluated in clinical trials and COVID-19 has been associated with decreases in sperm quality. The preferred procedures for systematic reviews and meta-analyses were followed in the conduct and reporting of this study. The average sperm parameters of all sperm donors’ multiple sperm donations were compared before and after receiving various COVID-19 vaccinations. Semen volume, total sperm motility, total sperm count, morphological change, and sperm concentration were the primary outcome measures. We compiled and analyzed the results of six studies on total sperm motility, six studies on semen volume, six studies on sperm concentration, two studies on morphological change, and two studies on total sperm count. Parameter comparisons with patients who had and had not been vaccinated were only reported in one of the included studies. When different types of COVID-19 vaccine injections were compared, no discernible differences in parameters were observed. According to the available data, the parameters of semen are unaffected by inactivated or messenger RNA (mRNA) COVID-19 vaccinations. To support these findings, additional prospectively designed research is required. |
format | Online Article Text |
id | pubmed-10411248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-104112482023-08-10 The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis Ma, Yu-Cheng Cheng, Chao Yuan, Chi Xiang, Li-Yuan Wen, Jun Jin, Xi Asian J Androl Original Article Published data were gathered for a meta-analysis to determine the difference in sperm parameters before and after administration of different types of coronavirus disease 2019 (COVID-19) vaccines, because the reproductive toxicity of COVID-19 vaccines has not yet been evaluated in clinical trials and COVID-19 has been associated with decreases in sperm quality. The preferred procedures for systematic reviews and meta-analyses were followed in the conduct and reporting of this study. The average sperm parameters of all sperm donors’ multiple sperm donations were compared before and after receiving various COVID-19 vaccinations. Semen volume, total sperm motility, total sperm count, morphological change, and sperm concentration were the primary outcome measures. We compiled and analyzed the results of six studies on total sperm motility, six studies on semen volume, six studies on sperm concentration, two studies on morphological change, and two studies on total sperm count. Parameter comparisons with patients who had and had not been vaccinated were only reported in one of the included studies. When different types of COVID-19 vaccine injections were compared, no discernible differences in parameters were observed. According to the available data, the parameters of semen are unaffected by inactivated or messenger RNA (mRNA) COVID-19 vaccinations. To support these findings, additional prospectively designed research is required. Wolters Kluwer - Medknow 2022-12-09 /pmc/articles/PMC10411248/ /pubmed/36510860 http://dx.doi.org/10.4103/aja2022100 Text en Copyright: © The Author(s)(2022) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ma, Yu-Cheng Cheng, Chao Yuan, Chi Xiang, Li-Yuan Wen, Jun Jin, Xi The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis |
title | The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis |
title_full | The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis |
title_fullStr | The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis |
title_full_unstemmed | The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis |
title_short | The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis |
title_sort | effect of covid-19 vaccines on sperm parameters: a systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411248/ https://www.ncbi.nlm.nih.gov/pubmed/36510860 http://dx.doi.org/10.4103/aja2022100 |
work_keys_str_mv | AT mayucheng theeffectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT chengchao theeffectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT yuanchi theeffectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT xiangliyuan theeffectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT wenjun theeffectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT jinxi theeffectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT mayucheng effectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT chengchao effectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT yuanchi effectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT xiangliyuan effectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT wenjun effectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis AT jinxi effectofcovid19vaccinesonspermparametersasystematicreviewandmetaanalysis |