Cargando…
Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases in men with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients between November 28, 2009, and February 4, 2021, from West China...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411254/ https://www.ncbi.nlm.nih.gov/pubmed/36348577 http://dx.doi.org/10.4103/aja202270 |
_version_ | 1785086624440254464 |
---|---|
author | Wang, Zhi-Peng Chen, Jun-Ru Zhao, Jin-Ge Zhu, Sha Zhang, Xing-Ming Liang, Jia-Yu He, Ben Ni, Yu-Chao Sun, Guang-Xi Shen, Peng-Fei Zeng, Hao |
author_facet | Wang, Zhi-Peng Chen, Jun-Ru Zhao, Jin-Ge Zhu, Sha Zhang, Xing-Ming Liang, Jia-Yu He, Ben Ni, Yu-Chao Sun, Guang-Xi Shen, Peng-Fei Zeng, Hao |
author_sort | Wang, Zhi-Peng |
collection | PubMed |
description | To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases in men with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients between November 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classified into 5 subgroups according to metastatic patterns as follows: simple bone metastases (G1), concomitant bone and regional lymph node (LN) metastases (G2), concomitant bone and nonregional LN (NRLN) metastases (G3), lung metastases (G4), and liver metastases (G5). In addition, patients in the G3 group were subclassified as G3a and G3b based on the LN metastatic plane (below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostate cancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showed that patients in G1 and G2 had relatively favorable clinical outcomes, patients in G3a and G4 had intermediate prognoses, and patients in G3b and G5 had the worst survival outcomes. We observed that patients in G3b had outcomes comparable to those in G5 but had a significantly worse prognosis than patients in G3a (median CFS: 8.2 months vs 14.3 months, P = 0.015; median OS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC, and the presence of concomitant bone and NRLN metastases is a valuable prognostic factor. Furthermore, our findings indicate that the farther the NRLNs are located, the more aggressive the disease is. |
format | Online Article Text |
id | pubmed-10411254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-104112542023-08-10 Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer Wang, Zhi-Peng Chen, Jun-Ru Zhao, Jin-Ge Zhu, Sha Zhang, Xing-Ming Liang, Jia-Yu He, Ben Ni, Yu-Chao Sun, Guang-Xi Shen, Peng-Fei Zeng, Hao Asian J Androl Original Article To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases in men with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients between November 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classified into 5 subgroups according to metastatic patterns as follows: simple bone metastases (G1), concomitant bone and regional lymph node (LN) metastases (G2), concomitant bone and nonregional LN (NRLN) metastases (G3), lung metastases (G4), and liver metastases (G5). In addition, patients in the G3 group were subclassified as G3a and G3b based on the LN metastatic plane (below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostate cancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showed that patients in G1 and G2 had relatively favorable clinical outcomes, patients in G3a and G4 had intermediate prognoses, and patients in G3b and G5 had the worst survival outcomes. We observed that patients in G3b had outcomes comparable to those in G5 but had a significantly worse prognosis than patients in G3a (median CFS: 8.2 months vs 14.3 months, P = 0.015; median OS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC, and the presence of concomitant bone and NRLN metastases is a valuable prognostic factor. Furthermore, our findings indicate that the farther the NRLNs are located, the more aggressive the disease is. Wolters Kluwer - Medknow 2022-11-01 /pmc/articles/PMC10411254/ /pubmed/36348577 http://dx.doi.org/10.4103/aja202270 Text en Copyright: © The Author(s)(2022) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Wang, Zhi-Peng Chen, Jun-Ru Zhao, Jin-Ge Zhu, Sha Zhang, Xing-Ming Liang, Jia-Yu He, Ben Ni, Yu-Chao Sun, Guang-Xi Shen, Peng-Fei Zeng, Hao Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
title | Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
title_full | Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
title_fullStr | Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
title_full_unstemmed | Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
title_short | Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
title_sort | regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411254/ https://www.ncbi.nlm.nih.gov/pubmed/36348577 http://dx.doi.org/10.4103/aja202270 |
work_keys_str_mv | AT wangzhipeng regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT chenjunru regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT zhaojinge regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT zhusha regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT zhangxingming regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT liangjiayu regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT heben regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT niyuchao regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT sunguangxi regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT shenpengfei regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer AT zenghao regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer |