Cargando…

Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer

To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases in men with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients between November 28, 2009, and February 4, 2021, from West China...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhi-Peng, Chen, Jun-Ru, Zhao, Jin-Ge, Zhu, Sha, Zhang, Xing-Ming, Liang, Jia-Yu, He, Ben, Ni, Yu-Chao, Sun, Guang-Xi, Shen, Peng-Fei, Zeng, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411254/
https://www.ncbi.nlm.nih.gov/pubmed/36348577
http://dx.doi.org/10.4103/aja202270
_version_ 1785086624440254464
author Wang, Zhi-Peng
Chen, Jun-Ru
Zhao, Jin-Ge
Zhu, Sha
Zhang, Xing-Ming
Liang, Jia-Yu
He, Ben
Ni, Yu-Chao
Sun, Guang-Xi
Shen, Peng-Fei
Zeng, Hao
author_facet Wang, Zhi-Peng
Chen, Jun-Ru
Zhao, Jin-Ge
Zhu, Sha
Zhang, Xing-Ming
Liang, Jia-Yu
He, Ben
Ni, Yu-Chao
Sun, Guang-Xi
Shen, Peng-Fei
Zeng, Hao
author_sort Wang, Zhi-Peng
collection PubMed
description To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases in men with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients between November 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classified into 5 subgroups according to metastatic patterns as follows: simple bone metastases (G1), concomitant bone and regional lymph node (LN) metastases (G2), concomitant bone and nonregional LN (NRLN) metastases (G3), lung metastases (G4), and liver metastases (G5). In addition, patients in the G3 group were subclassified as G3a and G3b based on the LN metastatic plane (below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostate cancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showed that patients in G1 and G2 had relatively favorable clinical outcomes, patients in G3a and G4 had intermediate prognoses, and patients in G3b and G5 had the worst survival outcomes. We observed that patients in G3b had outcomes comparable to those in G5 but had a significantly worse prognosis than patients in G3a (median CFS: 8.2 months vs 14.3 months, P = 0.015; median OS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC, and the presence of concomitant bone and NRLN metastases is a valuable prognostic factor. Furthermore, our findings indicate that the farther the NRLNs are located, the more aggressive the disease is.
format Online
Article
Text
id pubmed-10411254
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-104112542023-08-10 Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer Wang, Zhi-Peng Chen, Jun-Ru Zhao, Jin-Ge Zhu, Sha Zhang, Xing-Ming Liang, Jia-Yu He, Ben Ni, Yu-Chao Sun, Guang-Xi Shen, Peng-Fei Zeng, Hao Asian J Androl Original Article To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases in men with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients between November 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classified into 5 subgroups according to metastatic patterns as follows: simple bone metastases (G1), concomitant bone and regional lymph node (LN) metastases (G2), concomitant bone and nonregional LN (NRLN) metastases (G3), lung metastases (G4), and liver metastases (G5). In addition, patients in the G3 group were subclassified as G3a and G3b based on the LN metastatic plane (below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostate cancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showed that patients in G1 and G2 had relatively favorable clinical outcomes, patients in G3a and G4 had intermediate prognoses, and patients in G3b and G5 had the worst survival outcomes. We observed that patients in G3b had outcomes comparable to those in G5 but had a significantly worse prognosis than patients in G3a (median CFS: 8.2 months vs 14.3 months, P = 0.015; median OS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC, and the presence of concomitant bone and NRLN metastases is a valuable prognostic factor. Furthermore, our findings indicate that the farther the NRLNs are located, the more aggressive the disease is. Wolters Kluwer - Medknow 2022-11-01 /pmc/articles/PMC10411254/ /pubmed/36348577 http://dx.doi.org/10.4103/aja202270 Text en Copyright: © The Author(s)(2022) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Wang, Zhi-Peng
Chen, Jun-Ru
Zhao, Jin-Ge
Zhu, Sha
Zhang, Xing-Ming
Liang, Jia-Yu
He, Ben
Ni, Yu-Chao
Sun, Guang-Xi
Shen, Peng-Fei
Zeng, Hao
Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
title Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
title_full Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
title_fullStr Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
title_full_unstemmed Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
title_short Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
title_sort regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411254/
https://www.ncbi.nlm.nih.gov/pubmed/36348577
http://dx.doi.org/10.4103/aja202270
work_keys_str_mv AT wangzhipeng regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT chenjunru regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT zhaojinge regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT zhusha regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT zhangxingming regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT liangjiayu regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT heben regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT niyuchao regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT sunguangxi regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT shenpengfei regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer
AT zenghao regionallocationoflymphnodemetastasespredictssurvivalinpatientswithdenovometastaticprostatecancer