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The human RAP1 and GFAPɛ proteins increase γ-secretase activity in a yeast model system

Alzheimer's disease (AD) is an age-related disorder that results in progressive cognitive impairment and memory loss. Deposition of amyloid β (Aβ) peptides in senile plaques is a hallmark of AD. γ-secretase produces Aβ peptides, mostly as the soluble Aβ40 with fewer insoluble Aβ42 peptides. Rar...

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Detalles Bibliográficos
Autores principales:	Swanson, Mark J, Lewis, Kelsey N, Carpenter, Robert, Whetzel, Alexis, Bae, Nancy S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genetic Models of Rare Diseases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411568/ https://www.ncbi.nlm.nih.gov/pubmed/36929840 http://dx.doi.org/10.1093/g3journal/jkad057

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