Rationally designed stapled peptides allosterically inhibit PTBP1–RNA-binding

The diverse role of the splicing factor PTBP1 in human cells has been widely studied and was found to be a driver for several diseases. PTBP1 binds RNA through its RNA-recognition motifs which lack obvious pockets for inhibition. A unique transient helix has been described to be part of its first RN...

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Detalles Bibliográficos
Autores principales: Schmeing, Stefan, Amrahova, Gulshan, Bigler, Katrin, Chang, Jen-Yao, Openy, Joseph, Pal, Sunit, Posada, Laura, Gasper, Raphael, 't Hart, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411625/
https://www.ncbi.nlm.nih.gov/pubmed/37564416
http://dx.doi.org/10.1039/d3sc00985h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411625/
https://www.ncbi.nlm.nih.gov/pubmed/37564416
http://dx.doi.org/10.1039/d3sc00985h

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