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What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research

Speck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support...

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Detalles Bibliográficos
Autores principales:	Nagar, Abhinit, Bharadwaj, Ravi, Shaikh, Mohammad Omar Faruk, Roy, Abhishek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411722/ https://www.ncbi.nlm.nih.gov/pubmed/37564644 http://dx.doi.org/10.3389/fimmu.2023.1188864

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