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Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations

The government of India has adopted the elimination of vertical transmission of HIV as one of the five high-level goals under phase V of the National AIDS and STD Control Programme (NACP). In this paper, we present the data from HIV estimations 2021 for India and select States detailing the progress...

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Autores principales: Kumar, Pradeep, Das, Chinmoyee, Das, Udayabhanu, Kumar, Arvind, Priyam, Nidhi, Ranjan, Varsha, Sahu, Damodar, Rai, Sanjay K., Godbole, Sheela V., Arumugam, Elangovan, PVM, Lakshmi, Dutta, Shanta, Devi, H. Sanayaima, Pandey, Arvind, Reddy, Dandu Chandra Sekhar, Mehendale, Sanjay, Rajan, Shobini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411776/
https://www.ncbi.nlm.nih.gov/pubmed/37556441
http://dx.doi.org/10.1371/journal.pgph.0002270
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author Kumar, Pradeep
Das, Chinmoyee
Das, Udayabhanu
Kumar, Arvind
Priyam, Nidhi
Ranjan, Varsha
Sahu, Damodar
Rai, Sanjay K.
Godbole, Sheela V.
Arumugam, Elangovan
PVM, Lakshmi
Dutta, Shanta
Devi, H. Sanayaima
Pandey, Arvind
Reddy, Dandu Chandra Sekhar
Mehendale, Sanjay
Rajan, Shobini
author_facet Kumar, Pradeep
Das, Chinmoyee
Das, Udayabhanu
Kumar, Arvind
Priyam, Nidhi
Ranjan, Varsha
Sahu, Damodar
Rai, Sanjay K.
Godbole, Sheela V.
Arumugam, Elangovan
PVM, Lakshmi
Dutta, Shanta
Devi, H. Sanayaima
Pandey, Arvind
Reddy, Dandu Chandra Sekhar
Mehendale, Sanjay
Rajan, Shobini
author_sort Kumar, Pradeep
collection PubMed
description The government of India has adopted the elimination of vertical transmission of HIV as one of the five high-level goals under phase V of the National AIDS and STD Control Programme (NACP). In this paper, we present the data from HIV estimations 2021 for India and select States detailing the progress as well as the attributable causes for vertical transmissions. The NACP spearheads work on mathematical modelling to estimate HIV burden based on the periodically conducted sentinel surveillance for guiding program implementation and policymaking. Using the results of the latest round of HIV Estimations in 2021, we analysed the mother-to-child transmission (MTCT) during the perinatal and postnatal (breastfeeding) period. In 2021, overall, around 5,000 [3,000–7,800] vertical transmissions were estimated nationally with 58% being perinatal infections and remaining during breastfeeding. MTCT at 6 weeks was around 12.95% [9.45–16.02] with the final transmission rate at 24.25% [18.50–29.50]. Overall, 57% of vertical transmissions were among HIV-positive mothers who did not receive ART during pregnancy or breastfeeding, 19% among mothers who dropped off ART during pregnancy or delivery, and 18% among mothers who were infected during pregnancy or breastfeeding. There were significant variations between States. Depending upon the States, the programme needs to focus on the intervention domains of timely engagement in antenatal care-HIV testing-ART initiation as well as programme retention and adherence support. Equally important would be strengthening the strategic information to generate related evidence for inputting India and State-specific parameters improving the MTCT-related modelled estimates.
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spelling pubmed-104117762023-08-10 Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations Kumar, Pradeep Das, Chinmoyee Das, Udayabhanu Kumar, Arvind Priyam, Nidhi Ranjan, Varsha Sahu, Damodar Rai, Sanjay K. Godbole, Sheela V. Arumugam, Elangovan PVM, Lakshmi Dutta, Shanta Devi, H. Sanayaima Pandey, Arvind Reddy, Dandu Chandra Sekhar Mehendale, Sanjay Rajan, Shobini PLOS Glob Public Health Research Article The government of India has adopted the elimination of vertical transmission of HIV as one of the five high-level goals under phase V of the National AIDS and STD Control Programme (NACP). In this paper, we present the data from HIV estimations 2021 for India and select States detailing the progress as well as the attributable causes for vertical transmissions. The NACP spearheads work on mathematical modelling to estimate HIV burden based on the periodically conducted sentinel surveillance for guiding program implementation and policymaking. Using the results of the latest round of HIV Estimations in 2021, we analysed the mother-to-child transmission (MTCT) during the perinatal and postnatal (breastfeeding) period. In 2021, overall, around 5,000 [3,000–7,800] vertical transmissions were estimated nationally with 58% being perinatal infections and remaining during breastfeeding. MTCT at 6 weeks was around 12.95% [9.45–16.02] with the final transmission rate at 24.25% [18.50–29.50]. Overall, 57% of vertical transmissions were among HIV-positive mothers who did not receive ART during pregnancy or breastfeeding, 19% among mothers who dropped off ART during pregnancy or delivery, and 18% among mothers who were infected during pregnancy or breastfeeding. There were significant variations between States. Depending upon the States, the programme needs to focus on the intervention domains of timely engagement in antenatal care-HIV testing-ART initiation as well as programme retention and adherence support. Equally important would be strengthening the strategic information to generate related evidence for inputting India and State-specific parameters improving the MTCT-related modelled estimates. Public Library of Science 2023-08-09 /pmc/articles/PMC10411776/ /pubmed/37556441 http://dx.doi.org/10.1371/journal.pgph.0002270 Text en © 2023 Kumar et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kumar, Pradeep
Das, Chinmoyee
Das, Udayabhanu
Kumar, Arvind
Priyam, Nidhi
Ranjan, Varsha
Sahu, Damodar
Rai, Sanjay K.
Godbole, Sheela V.
Arumugam, Elangovan
PVM, Lakshmi
Dutta, Shanta
Devi, H. Sanayaima
Pandey, Arvind
Reddy, Dandu Chandra Sekhar
Mehendale, Sanjay
Rajan, Shobini
Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
title Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
title_full Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
title_fullStr Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
title_full_unstemmed Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
title_short Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations
title_sort augmenting progress on the elimination of vertical transmissions of hiv in india: insights from spectrum-based hiv burden estimations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411776/
https://www.ncbi.nlm.nih.gov/pubmed/37556441
http://dx.doi.org/10.1371/journal.pgph.0002270
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