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Basement membrane dynamics and mechanics in tissue morphogenesis
The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies epithelia and surrounds most organs. During development, the BM is highly dynamic and simultaneously provides mechanical properties that stabilize tissue structure and shape organs. Moreover, it is important f...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Company of Biologists Ltd
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411871/ https://www.ncbi.nlm.nih.gov/pubmed/37531197 http://dx.doi.org/10.1242/bio.059980 |
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author | Töpfer, Uwe |
author_facet | Töpfer, Uwe |
author_sort | Töpfer, Uwe |
collection | PubMed |
description | The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies epithelia and surrounds most organs. During development, the BM is highly dynamic and simultaneously provides mechanical properties that stabilize tissue structure and shape organs. Moreover, it is important for cell polarity, cell migration, and cell signaling. Thereby BM diverges regarding molecular composition, structure, and modes of assembly. Different BM organization leads to various physical features. The mechanisms that regulate BM composition and structure and how this affects mechanical properties are not fully understood. Recent studies show that precise control of BM deposition or degradation can result in BMs with locally different protein densities, compositions, thicknesses, or polarization. Such heterogeneous matrices can induce temporospatial force anisotropy and enable tissue sculpting. In this Review, I address recent findings that provide new perspectives on the role of the BM in morphogenesis. |
format | Online Article Text |
id | pubmed-10411871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-104118712023-08-10 Basement membrane dynamics and mechanics in tissue morphogenesis Töpfer, Uwe Biol Open Review The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies epithelia and surrounds most organs. During development, the BM is highly dynamic and simultaneously provides mechanical properties that stabilize tissue structure and shape organs. Moreover, it is important for cell polarity, cell migration, and cell signaling. Thereby BM diverges regarding molecular composition, structure, and modes of assembly. Different BM organization leads to various physical features. The mechanisms that regulate BM composition and structure and how this affects mechanical properties are not fully understood. Recent studies show that precise control of BM deposition or degradation can result in BMs with locally different protein densities, compositions, thicknesses, or polarization. Such heterogeneous matrices can induce temporospatial force anisotropy and enable tissue sculpting. In this Review, I address recent findings that provide new perspectives on the role of the BM in morphogenesis. The Company of Biologists Ltd 2023-08-02 /pmc/articles/PMC10411871/ /pubmed/37531197 http://dx.doi.org/10.1242/bio.059980 Text en © 2023. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Töpfer, Uwe Basement membrane dynamics and mechanics in tissue morphogenesis |
title | Basement membrane dynamics and mechanics in tissue morphogenesis |
title_full | Basement membrane dynamics and mechanics in tissue morphogenesis |
title_fullStr | Basement membrane dynamics and mechanics in tissue morphogenesis |
title_full_unstemmed | Basement membrane dynamics and mechanics in tissue morphogenesis |
title_short | Basement membrane dynamics and mechanics in tissue morphogenesis |
title_sort | basement membrane dynamics and mechanics in tissue morphogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411871/ https://www.ncbi.nlm.nih.gov/pubmed/37531197 http://dx.doi.org/10.1242/bio.059980 |
work_keys_str_mv | AT topferuwe basementmembranedynamicsandmechanicsintissuemorphogenesis |