Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1

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Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB). PR-DUB cleaves H2AK119Ub to restrict focal H2AK119Ub at Polycomb target sites and to protect active genes from aberrant silencing. The...

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Detalles Bibliográficos
Autores principales: Thomas, Jonathan F., Valencia-Sánchez, Marco Igor, Tamburri, Simone, Gloor, Susan L., Rustichelli, Samantha, Godínez-López, Victoria, De Ioannes, Pablo, Lee, Rachel, Abini-Agbomson, Stephen, Gretarsson, Kristjan, Burg, Jonathan M., Hickman, Allison R., Sun, Lu, Gopinath, Saarang, Taylor, Hailey F., Sun, Zu-Wen, Ezell, Ryan J., Vaidya, Anup, Meiners, Matthew J., Cheek, Marcus A., Rice, William J., Svetlov, Vladimir, Nudler, Evgeny, Lu, Chao, Keogh, Michael-Christopher, Pasini, Diego, Armache, Karim-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411902/
https://www.ncbi.nlm.nih.gov/pubmed/37556531
http://dx.doi.org/10.1126/sciadv.adg9832
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