TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

Tumor progression locus 2 (TPL2) (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and is required for microglia-mediated neuron death in vitro. In acute in vivo neuroinflammation sett...

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Detalles Bibliográficos
Autores principales: Wang, Yuanyuan, Wu, Tiffany, Tsai, Ming-Chi, Rezzonico, Mitchell G, Abdel-Haleem, Alyaa M, Xie, Luke, Gandham, Vineela D, Ngu, Hai, Stark, Kimberly, Glock, Caspar, Xu, Daqi, Foreman, Oded, Friedman, Brad A, Sheng, Morgan, Hanson, Jesse E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411973/
https://www.ncbi.nlm.nih.gov/pubmed/37555828
http://dx.doi.org/10.7554/eLife.83451

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