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Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task

Stimulants like methamphetamine (MA) affect motivated behaviors via actions on circuits mediating mood, attention, and reward. Few studies examined the effects of single doses of stimulants on reward circuits during anticipation and receipt of rewards and losses. Here, we examined the effects of MA...

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Autores principales: Molla, Hanna, Keedy, Sarah, DeBrosse, Joseph, de Wit, Harriet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412021/
https://www.ncbi.nlm.nih.gov/pubmed/37565072
http://dx.doi.org/10.1093/texcom/tgad014
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author Molla, Hanna
Keedy, Sarah
DeBrosse, Joseph
de Wit, Harriet
author_facet Molla, Hanna
Keedy, Sarah
DeBrosse, Joseph
de Wit, Harriet
author_sort Molla, Hanna
collection PubMed
description Stimulants like methamphetamine (MA) affect motivated behaviors via actions on circuits mediating mood, attention, and reward. Few studies examined the effects of single doses of stimulants on reward circuits during anticipation and receipt of rewards and losses. Here, we examined the effects of MA (20 mg) or placebo in a within-subject, double-blind study with healthy adults (n = 43). During 2 fMRI sessions, participants completed the monetary incentive delay task. Primary outcome measures were BOLD activation in selected regions of interest during anticipation and receipt of monetary rewards and losses. Secondary analyses included behavioral measures, whole brain analysis, and arterial spin labeling. MA produced its expected behavioral effects and increased neural activation in the ventral striatum and anterior insula during anticipation of monetary loss versus non-loss. MA did not affect activation during anticipation of gains, or during receipt of wins or losses. MA significantly reduced cerebral blood flow in the striatum and insula. The present finding that a stimulant enhances the responses of striatal and insular regions to upcoming loss suggests that this system may be sensitive to the salience of upcoming events. The finding adds to a complex body of evidence regarding the effects of stimulant drugs on neural processes during motivated behaviors.
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spelling pubmed-104120212023-08-10 Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task Molla, Hanna Keedy, Sarah DeBrosse, Joseph de Wit, Harriet Cereb Cortex Commun Original Article Stimulants like methamphetamine (MA) affect motivated behaviors via actions on circuits mediating mood, attention, and reward. Few studies examined the effects of single doses of stimulants on reward circuits during anticipation and receipt of rewards and losses. Here, we examined the effects of MA (20 mg) or placebo in a within-subject, double-blind study with healthy adults (n = 43). During 2 fMRI sessions, participants completed the monetary incentive delay task. Primary outcome measures were BOLD activation in selected regions of interest during anticipation and receipt of monetary rewards and losses. Secondary analyses included behavioral measures, whole brain analysis, and arterial spin labeling. MA produced its expected behavioral effects and increased neural activation in the ventral striatum and anterior insula during anticipation of monetary loss versus non-loss. MA did not affect activation during anticipation of gains, or during receipt of wins or losses. MA significantly reduced cerebral blood flow in the striatum and insula. The present finding that a stimulant enhances the responses of striatal and insular regions to upcoming loss suggests that this system may be sensitive to the salience of upcoming events. The finding adds to a complex body of evidence regarding the effects of stimulant drugs on neural processes during motivated behaviors. Oxford University Press 2023-07-20 /pmc/articles/PMC10412021/ /pubmed/37565072 http://dx.doi.org/10.1093/texcom/tgad014 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Molla, Hanna
Keedy, Sarah
DeBrosse, Joseph
de Wit, Harriet
Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
title Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
title_full Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
title_fullStr Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
title_full_unstemmed Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
title_short Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
title_sort methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412021/
https://www.ncbi.nlm.nih.gov/pubmed/37565072
http://dx.doi.org/10.1093/texcom/tgad014
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