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Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (TTP) is a microangiopathy characterized by mechanical hemolytic anemia, resulting in end-organ damage. We describe a case of TTP which presented as an ischemic stroke. The patient presented with stroke as the primary manifestation of TTP despite a normal platelet...

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Detalles Bibliográficos
Autores principales: Adimora, Ijele, Zhang, Bingnan, Idowu, Modupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412150/
https://www.ncbi.nlm.nih.gov/pubmed/37564991
http://dx.doi.org/10.1155/2023/7070189
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author Adimora, Ijele
Zhang, Bingnan
Idowu, Modupe
author_facet Adimora, Ijele
Zhang, Bingnan
Idowu, Modupe
author_sort Adimora, Ijele
collection PubMed
description Thrombotic thrombocytopenic purpura (TTP) is a microangiopathy characterized by mechanical hemolytic anemia, resulting in end-organ damage. We describe a case of TTP which presented as an ischemic stroke. The patient presented with stroke as the primary manifestation of TTP despite a normal platelet count and mildly elevated lactate dehydrogenase level (LDH). The patient underwent two transfusions of fresh frozen plasma (FFP), and ADAMTS13 levels confirmed the diagnosis of TTP after discharge. This case demonstrates the importance of maintaining a high index of suspicion for TTP in the setting of normal laboratory values and reveals the many atypical manifestations of TTP.
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spelling pubmed-104121502023-08-10 Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura Adimora, Ijele Zhang, Bingnan Idowu, Modupe Case Rep Med Case Report Thrombotic thrombocytopenic purpura (TTP) is a microangiopathy characterized by mechanical hemolytic anemia, resulting in end-organ damage. We describe a case of TTP which presented as an ischemic stroke. The patient presented with stroke as the primary manifestation of TTP despite a normal platelet count and mildly elevated lactate dehydrogenase level (LDH). The patient underwent two transfusions of fresh frozen plasma (FFP), and ADAMTS13 levels confirmed the diagnosis of TTP after discharge. This case demonstrates the importance of maintaining a high index of suspicion for TTP in the setting of normal laboratory values and reveals the many atypical manifestations of TTP. Hindawi 2023-08-02 /pmc/articles/PMC10412150/ /pubmed/37564991 http://dx.doi.org/10.1155/2023/7070189 Text en Copyright © 2023 Ijele Adimora et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Adimora, Ijele
Zhang, Bingnan
Idowu, Modupe
Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura
title Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura
title_full Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura
title_fullStr Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura
title_full_unstemmed Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura
title_short Recurrent Strokes in a Woman with a History of Thrombotic Thrombocytopenic Purpura
title_sort recurrent strokes in a woman with a history of thrombotic thrombocytopenic purpura
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412150/
https://www.ncbi.nlm.nih.gov/pubmed/37564991
http://dx.doi.org/10.1155/2023/7070189
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