Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer

Netrin-1 is upregulated in cancers as a protumoural mechanism(1). Here we describe netrin-1 upregulation in a majority of human endometrial carcinomas (ECs) and demonstrate that netrin-1 blockade, using an anti-netrin-1 antibody (NP137), is effective in reduction of tumour progression in an EC mouse...

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Detalles Bibliográficos
Autores principales: Cassier, Philippe A., Navaridas, Raul, Bellina, Melanie, Rama, Nicolas, Ducarouge, Benjamin, Hernandez-Vargas, Hector, Delord, Jean-Pierre, Lengrand, Justine, Paradisi, Andrea, Fattet, Laurent, Garin, Gwenaële, Gheit, Hanane, Dalban, Cecile, Pastushenko, Ievgenia, Neves, David, Jelin, Remy, Gadot, Nicolas, Braissand, Nicolas, Léon, Sophie, Degletagne, Cyril, Matias-Guiu, Xavier, Devouassoux-Shisheboran, Mojgan, Mery-Lamarche, Eliane, Allard, Justine, Zindy, Egor, Decaestecker, Christine, Salmon, Isabelle, Perol, David, Dolcet, Xavi, Ray-Coquard, Isabelle, Blanpain, Cédric, Bernet, Agnès, Mehlen, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412451/
https://www.ncbi.nlm.nih.gov/pubmed/37532934
http://dx.doi.org/10.1038/s41586-023-06367-z

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