NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model

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Radiotherapy (XRT), a well-known activator of the inflammasome and immune priming, is in part capable of reversing resistance to anti-PD1 treatment. The NLRP3 inflammasome is a pattern recognition receptor which is activated by both exogenous and endogenous stimuli, leading to a downstream inflammat...

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Detalles Bibliográficos
Autores principales: Barsoumian, Hampartsoum B., He, Kewen, Hsu, Ethan, Bertolet, Genevieve, Sezen, Duygu, Hu, Yun, Riad, Thomas S., Cortez, Maria Angelica, Welsh, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412467/
https://www.ncbi.nlm.nih.gov/pubmed/37289257
http://dx.doi.org/10.1007/s00262-023-03471-x
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