Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally heterogeneous genes have been associated with the familial form of this disorder (fALS), depicting an extremely complex pathogenic landscape. This heterogeneity...

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Detalles Bibliográficos
Autores principales: Aly, Amr, Laszlo, Zsofia I., Rajkumar, Sandeep, Demir, Tugba, Hindley, Nicole, Lamont, Douglas J., Lehmann, Johannes, Seidel, Mira, Sommer, Daniel, Franz-Wachtel, Mirita, Barletta, Francesca, Heumos, Simon, Czemmel, Stefan, Kabashi, Edor, Ludolph, Albert, Boeckers, Tobias M., Henstridge, Christopher M., Catanese, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412488/
https://www.ncbi.nlm.nih.gov/pubmed/37488208
http://dx.doi.org/10.1007/s00401-023-02611-y

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