Comparative assessment of anti-cancer drugs against NUDT15 variants to prevent leucopenia side effect in leukemia patients

BACKGROUND: Human nucleotide triphosphate diphosphatase (NUDT15) is one of the essential proteins involved in the hydrolysis of anti-cancer drugs against leukemia. Polymorphisms in NUDT15 significantly affect the hydrolysis activity that leads to side effects, including leucopenia. Drugs having a be...

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Detalles Bibliográficos
Autores principales: V., Janakiraman, M., Sudhan, Alsharif, Khalaf F., Halawani, Ibrahim F., Ahmed, Shiek S. S. J., Patil, Shankargouda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412517/
https://www.ncbi.nlm.nih.gov/pubmed/37556043
http://dx.doi.org/10.1186/s43141-023-00538-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412517/
https://www.ncbi.nlm.nih.gov/pubmed/37556043
http://dx.doi.org/10.1186/s43141-023-00538-1

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