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Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis
We previously confirmed that a strain of Lactobacillus oris isolated from the fecal samples of healthy Hainan centenarian having potent lipid-lowering ability in HepG2 cells; and this study was to investigate the effect of the stain on non-alcoholic fatty liver in mice in vivio. The Lactobacillus or...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412569/ https://www.ncbi.nlm.nih.gov/pubmed/37558739 http://dx.doi.org/10.1038/s41598-023-38530-x |
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author | Zhao, Yiming Li, Congyong Luan, Zhe Chen, Jun Wang, Cong Jing, Yujia Qi, Shirui Zhao, Zhizhuang Zhang, Hanwen Wu, Junling Chen, Yi Li, Zhuanyu Zhao, Bowen Wang, Shufang Yang, Yunsheng Sun, Gang |
author_facet | Zhao, Yiming Li, Congyong Luan, Zhe Chen, Jun Wang, Cong Jing, Yujia Qi, Shirui Zhao, Zhizhuang Zhang, Hanwen Wu, Junling Chen, Yi Li, Zhuanyu Zhao, Bowen Wang, Shufang Yang, Yunsheng Sun, Gang |
author_sort | Zhao, Yiming |
collection | PubMed |
description | We previously confirmed that a strain of Lactobacillus oris isolated from the fecal samples of healthy Hainan centenarian having potent lipid-lowering ability in HepG2 cells; and this study was to investigate the effect of the stain on non-alcoholic fatty liver in mice in vivio. The Lactobacillus oris strain isolated from Hainan centenarian fecal samples were frozen stored in our laboratory. Thirty ob/ob mice (10 in each group) were orally gavaged with Lactobacillus oris (Lactobacillus, 5 × 10(9) cfu), mixed probiotics (Mixed, 5 × 10(9) cfu, a mixture with known lipid-lowering ability), or culture medium (Control) respectively. Lactobacillus oris isolated from fecal samples of Hainan centenarians showed significantly in vivo lipid lowering ability compared with the controls, and the ability was comparable with mixed probiotics strains in mice The possible mechanisms of lipid-lowering of probiotics and Lactobacillus oris may be associated with HMGR inhibition to suppress the synthesis of endogenous cholesterol; bile acids reabsorption, and intestinal FXR-FGF15 signaling pathways promoting the cholesterol conversion into bile acids secretion. |
format | Online Article Text |
id | pubmed-10412569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104125692023-08-11 Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis Zhao, Yiming Li, Congyong Luan, Zhe Chen, Jun Wang, Cong Jing, Yujia Qi, Shirui Zhao, Zhizhuang Zhang, Hanwen Wu, Junling Chen, Yi Li, Zhuanyu Zhao, Bowen Wang, Shufang Yang, Yunsheng Sun, Gang Sci Rep Article We previously confirmed that a strain of Lactobacillus oris isolated from the fecal samples of healthy Hainan centenarian having potent lipid-lowering ability in HepG2 cells; and this study was to investigate the effect of the stain on non-alcoholic fatty liver in mice in vivio. The Lactobacillus oris strain isolated from Hainan centenarian fecal samples were frozen stored in our laboratory. Thirty ob/ob mice (10 in each group) were orally gavaged with Lactobacillus oris (Lactobacillus, 5 × 10(9) cfu), mixed probiotics (Mixed, 5 × 10(9) cfu, a mixture with known lipid-lowering ability), or culture medium (Control) respectively. Lactobacillus oris isolated from fecal samples of Hainan centenarians showed significantly in vivo lipid lowering ability compared with the controls, and the ability was comparable with mixed probiotics strains in mice The possible mechanisms of lipid-lowering of probiotics and Lactobacillus oris may be associated with HMGR inhibition to suppress the synthesis of endogenous cholesterol; bile acids reabsorption, and intestinal FXR-FGF15 signaling pathways promoting the cholesterol conversion into bile acids secretion. Nature Publishing Group UK 2023-08-09 /pmc/articles/PMC10412569/ /pubmed/37558739 http://dx.doi.org/10.1038/s41598-023-38530-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhao, Yiming Li, Congyong Luan, Zhe Chen, Jun Wang, Cong Jing, Yujia Qi, Shirui Zhao, Zhizhuang Zhang, Hanwen Wu, Junling Chen, Yi Li, Zhuanyu Zhao, Bowen Wang, Shufang Yang, Yunsheng Sun, Gang Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
title | Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
title_full | Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
title_fullStr | Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
title_full_unstemmed | Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
title_short | Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
title_sort | lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412569/ https://www.ncbi.nlm.nih.gov/pubmed/37558739 http://dx.doi.org/10.1038/s41598-023-38530-x |
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