Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles

Interleukin-2 (IL-2) engineered versions, with biased immunological functions, have emerged from yeast display and rational design. Here we reshaped the human IL-2 interface with the IL-2 receptor beta chain through the screening of phage-displayed libraries. Multiple beta super-binders were obtaine...

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Detalles Bibliográficos
Autores principales: Rojas, Gertrudis, Relova-Hernández, Ernesto, Pérez-Riverón, Annia, Castro-Martínez, Camila, Diaz-Bravo, Osmany, Infante, Yanelys Cabrera, Gómez, Tania, Solozábal, Joaquín, DíazBravo, Ana Beatriz, Schubert, Maren, Becker, Marlies, Pérez-Massón, Beatriz, Pérez-Martínez, Dayana, Alvarez-Arzola, Rydell, Guirola, Osmany, Chinea, Glay, Graca, Luis, Dübel, Stefan, León, Kalet, Carmenate, Tania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412584/
https://www.ncbi.nlm.nih.gov/pubmed/37558752
http://dx.doi.org/10.1038/s42003-023-05188-0

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